Glycyrrhetinic acid alleviates radiation-induced lung injury in mice.
J Radiat Res
; 58(1): 41-47, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-27672101
ABSTRACT
Radiation-induced lung injury (RILI) is a common complication of thoracic radiotherapy, but efficacious therapy for RILI is lacking. This study ascertained whether glycyrrhetinic acid (GA; a functional hydrolyzed product of glycyrrhizic acid, which is extracted from herb licorice) can protect against RILI and investigated its relationship to the transforming growth factor (TGF)-ß1/Smads signaling pathway. C57BL/6 mice were divided into four groups a control group, a GA group and two irradiation (IR) groups. IR groups were exposed to a single fraction of X-rays (12 Gy) to the thorax and administered normal saline (IR + NS group) or GA (IR + GA group). Two days and 17 days after irradiation, histologic analyses were performed to assess the degree of lung injury, and the expression of TGF-ß1, Smad2, Smad3 and Smad7 was recorded. GA administration mitigated the histologic changes of lung injury 2 days and 17 days after irradiation. Protein and mRNA expression of TGF-ß1, Smad2 and Smad3, and the mRNA level of Smad7, in lung tissue were significantly elevated after irradiation. GA decreased expression of TGF-ß1, Smad2 and Smad3 in lung tissue, but did not increase Smad7 expression. GA can protect against early-stage RILI. This protective effect may be associated with inhibition of the TGF-ß1/Smads signaling pathway.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
/
Lesão Pulmonar
/
Ácido Glicirretínico
Limite:
Animals
Idioma:
En
Revista:
J Radiat Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China