Moderate Alcohol Consumption and Chronic Disease: The Case for a Long-Term Trial.
Alcohol Clin Exp Res
; 40(11): 2283-2291, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27688006
ABSTRACT
Drinking within recommended limits is highly prevalent in much of the world, and strong epidemiological associations exist between moderate alcohol consumption and risk of several major chronic diseases, including coronary heart disease, diabetes, and breast cancer. In many cases, plausible biological mediators for these associations have been identified in randomized trials, but gold standard evidence that moderate drinking causes or prevents any chronic disease remains elusive and important concerns about available evidence have been raised. Although long-term randomized trials to test the observed associations have been termed impossible, clinical investigators have now successfully completed randomized trials of complex nutritional interventions in a variety of settings, along with trials of alcohol consumption itself of up to 2 years duration. The successful completion of these trials suggests that objections to the execution of a full-scale, long-term clinical trial of moderate drinking on chronic disease are increasingly untenable. We present potential lessons learned for such a trial and discuss key features to maximize its feasibility and value.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Bebidas Alcoólicas
/
Doença Crônica
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
Alcohol Clin Exp Res
Ano de publicação:
2016
Tipo de documento:
Article