Acrolein increases macrophage atherogenicity in association with gut microbiota remodeling in atherosclerotic mice: protective role for the polyphenol-rich pomegranate juice.

Rom, Oren; Korach-Rechtman, Hila; Hayek, Tony; Danin-Poleg, Yael; Bar, Haim; Kashi, Yechezkel; Aviram, Michael

Acrolein increases macrophage atherogenicity in association with gut microbiota remodeling in atherosclerotic mice: protective role for the polyphenol-rich pomegranate juice.

Rom, Oren; Korach-Rechtman, Hila; Hayek, Tony; Danin-Poleg, Yael; Bar, Haim; Kashi, Yechezkel; Aviram, Michael.

Afiliação

Rom O; The Lipid Research Laboratory, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Efron 1, Bat Galim, 31096, Haifa, Israel. orenrom@tx.technion.ac.il.
Korach-Rechtman H; Laboratory of Applied Genomics, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
Hayek T; The Lipid Research Laboratory, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Efron 1, Bat Galim, 31096, Haifa, Israel.
Danin-Poleg Y; Department of Internal Medicine E, Rambam Health Care Campus, Haifa, Israel.
Bar H; Laboratory of Applied Genomics, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
Kashi Y; Department of Statistics, University of Connecticut, Storrs, CT, USA.
Aviram M; Laboratory of Applied Genomics, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, Israel.

Arch Toxicol ; 91(4): 1709-1725, 2017 Apr.

Article em En | MEDLINE | ID: mdl-27696135

Assuntos

Acroleína/toxicidade; Aterosclerose/prevenção & controle; Lythraceae/química; Macrófagos/efeitos dos fármacos; Polifenóis/farmacologia; Animais; Apolipoproteínas E/genética; Aterosclerose/induzido quimicamente; Linhagem Celular; Modelos Animais de Doenças; Microbioma Gastrointestinal/efeitos dos fármacos; Metabolismo dos Lipídeos/efeitos dos fármacos; Macrófagos/patologia; Macrófagos Peritoneais/efeitos dos fármacos; Macrófagos Peritoneais/patologia; Masculino; Camundongos; Camundongos Knockout; Estresse Oxidativo/efeitos dos fármacos; Polifenóis/isolamento & purificação

Palavras-chave

Acrolein; Gut microbiota; Lipid metabolism; Macrophage foam cells; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acroleína / Lythraceae / Aterosclerose / Polifenóis / Macrófagos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Arch Toxicol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Israel

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