Antithrombotic activity of recombinant hirudin in the rat: a comparative study with heparin.
Thromb Res
; 54(5): 435-45, 1989 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-2772867
ABSTRACT
Hirudin, a potent inhibitor of blood coagulation, differs in its antithrombotic activity according to the source of isolation. It was therefore of interest to study recombinant hirudin. Hirudin was obtained by a genetic process from E. coli. Its antithrombotic action was investigated in an experimental (rat) model of venous thrombosis and was compared to heparin whose results are known. Heparin (400 micrograms/kg) and hirudin (12.5, 25 and 50 micrograms/kg) present an antithrombotic effect and limit the extension of an existing thrombus (p less than 0.05). Higher heparin dosages increase the bleeding time mean value (p less than 0.05) whereas hirudin does not. So, recombinant hirudin presents the same antithrombotic action as heparin but with very inferior dosage. This activity seems not dose-dependent and is associated to weak hemorrhagic effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombose
/
Heparina
/
Terapia com Hirudina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Thromb Res
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
França