Diabetes-linked transcription factor HNF4&#945; regulates metabolism of endogenous methylarginines and ß-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.

Burdin, Dmitry V; Kolobov, Alexey A; Brocker, Chad; Soshnev, Alexey A; Samusik, Nikolay; Demyanov, Anton V; Brilloff, Silke; Jarzebska, Natalia; Martens-Lobenhoffer, Jens; Mieth, Maren; Maas, Renke; Bornstein, Stefan R; Bode-Böger, Stefanie M; Gonzalez, Frank; Weiss, Norbert; Rodionov, Roman N

Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and ß-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.

Burdin, Dmitry V; Kolobov, Alexey A; Brocker, Chad; Soshnev, Alexey A; Samusik, Nikolay; Demyanov, Anton V; Brilloff, Silke; Jarzebska, Natalia; Martens-Lobenhoffer, Jens; Mieth, Maren; Maas, Renke; Bornstein, Stefan R; Bode-Böger, Stefanie M; Gonzalez, Frank; Weiss, Norbert; Rodionov, Roman N.

Afiliação

Burdin DV; Department of Physiology, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
Kolobov AA; Department of Biochemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
Brocker C; National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Soshnev AA; The Rockefeller University, New York, NY, 10065, USA.
Samusik N; Stanford University School of Medicine, Stanford, CA, 94305, USA.
Demyanov AV; Institute of Highly Pure Biopreparations, 197110 Saint Petersburg, Russia.
Brilloff S; University Center for Vascular Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
Jarzebska N; University Center for Vascular Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
Martens-Lobenhoffer J; Institute of Clinical Pharmacology, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Mieth M; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Maas R; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Bornstein SR; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Bode-Böger SM; Institute of Clinical Pharmacology, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Gonzalez F; National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Weiss N; University Center for Vascular Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
Rodionov RN; University Center for Vascular Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

Sci Rep ; 6: 35503, 2016 10 18.

Article em En | MEDLINE | ID: mdl-27752141

Assuntos

Doenças Cardiovasculares/genética; Diabetes Mellitus Tipo 2/genética; Fator 4 Nuclear de Hepatócito/genética; Fígado/fisiologia; Transaminases/genética; Ácidos Aminoisobutíricos/metabolismo; Animais; Arginina/análogos & derivados; Arginina/metabolismo; Doenças Cardiovasculares/complicações; Linhagem Celular; Diabetes Mellitus Tipo 2/complicações; Regulação da Expressão Gênica; Fator 4 Nuclear de Hepatócito/metabolismo; Humanos; Fígado/patologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Polimorfismo de Nucleotídeo Único; Regiões Promotoras Genéticas/genética; RNA Interferente Pequeno/genética; Risco

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Diabetes Mellitus Tipo 2 / Fator 4 Nuclear de Hepatócito / Transaminases / Fígado Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Federação Russa

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