[Comparison of the antiemetic effectiveness of high-dose corticosteroids with synacthene in nausea induced by chemotherapy: results of a randomized study]. / Comparaison de l'efficacité anti-émétique de corticoïdes à fortes doses à celle du synacthène lors de nausées induites par la chimiothérapie: résultats d'une étude randomisée.

ABSTRACT

One hundred two patients submitted to intensive chemotherapy were included in a randomized study with cross over comparing for the second course two anti-emetics tetracosactide (D1 3 mg, D2 and D3 2 mg/d) and methylprednisolone (D1 240 mg, D2 and D3 160 mg/d). Most patients presented with malignant lymphoma. All patients experienced nausea and emesis during first course of chemotherapy. Results were similar in both groups, respectively for tetracosactide and methylprednisolone no nausea 37 versus 40%, less than 3 emesis 69% versus 73%. Secondary effects were observed in 5 and 8% of cases. Tetracosactide with a schedule of 7 mg for 3 days gives the same results than methylprednisolone 560 mg for 3 days in chemotherapy induced nausea and emesis prevention.