Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.
J Med Chem
; 32(5): 1057-62, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2785211
ABSTRACT
A series of halogenated racemic analogues of dexetimide (1) was synthesized and their affinity for the muscarinic cholinergic receptor measured. One analogue, 4-iododexetimide (21), was efficiently labeled with 125I and 123I at high specific activity. In vitro binding studies and in vivo biodistribution studies suggest that 123I-labeled 21 may be useful for imaging muscarinic cholinergic receptors in the living human brain with single photon emission computed tomography.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parassimpatolíticos
/
Piperidinas
/
Dexetimida
/
Receptores Muscarínicos
/
Radioisótopos do Iodo
/
Marcação por Isótopo
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1989
Tipo de documento:
Article