The Impact of Pregnancy on Myotonic Dystrophy: A Registry-Based Study.
J Neuromuscul Dis
; 2(4): 447-452, 2015 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-27858748
ABSTRACT
BACKGROUND:
The rate of symptom progression during pregnancy in myotonic dystrophy (DM) is not currently known. Further, there is little data regarding the rate of pregnancy complications and neonatal outcomes in DM.OBJECTIVE:
This study assesses symptom progression and complication rates during pregnancy in women with DM.METHODS:
DM women completed surveys regarding their prior pregnancies. Participants identified complications during their pregnancies and completed the Myotonic Dystrophy Health Index-Short Form (MDHI-SF) to measure their disease burden and identify the severity of select symptoms six-months prior to, during, and six-months after their first pregnancy.RESULTS:
152 women with DM reported on 375 pregnancies. Among these pregnancies, there was a 32.5% miscarriage rate. Some complications were common including pre-term labor (27.8%), pre-eclampsia (10.4%), and peripartum hemorrhage (13.9%). Participants' perception of their mobility and ability to perform activities, as measured by the MDHI-SF, worsened during pregnancy and did not recover during the post-partum period.DISCUSSION:
Miscarriage, maternal disease progression during pregnancy, and other pregnancy related complications may occur in DM. Women with DM should be counseled on these potential risks prior to considering pregnancy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Neuromuscul Dis
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos