Cholinesterases inhibition and molecular modeling studies of piperidyl-thienyl and 2-pyrazoline derivatives of chalcones.

Shah, Muhammad Shakil; Khan, Shafi Ullah; Ejaz, Syeda Abida; Afridi, Saifullah; Rizvi, Syed Umar Farooq; Najam-Ul-Haq, Muhammad; Iqbal, Jamshed

Shah, Muhammad Shakil; Khan, Shafi Ullah; Ejaz, Syeda Abida; Afridi, Saifullah; Rizvi, Syed Umar Farooq; Najam-Ul-Haq, Muhammad; Iqbal, Jamshed.

Afiliação

Shah MS; Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad-22060, Abbottabad, Pakistan; Division of Analytical Chemistry, Institute of Chemical Science, Bahauddin Zakariya University, 60800, Multan, Pakistan.
Khan SU; Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad-22060, Abbottabad, Pakistan.
Ejaz SA; Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad-22060, Abbottabad, Pakistan.
Afridi S; Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad-22060, Abbottabad, Pakistan.
Rizvi SUF; Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
Najam-Ul-Haq M; Division of Analytical Chemistry, Institute of Chemical Science, Bahauddin Zakariya University, 60800, Multan, Pakistan.
Iqbal J; Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad-22060, Abbottabad, Pakistan. Electronic address: drjamshed@ciit.net.pk.

Biochem Biophys Res Commun ; 482(4): 615-624, 2017 Jan 22.

Article em En | MEDLINE | ID: mdl-27865835

Assuntos

Acetilcolinesterase/metabolismo; Butirilcolinesterase/metabolismo; Chalconas/química; Chalconas/farmacologia; Inibidores da Colinesterase/química; Inibidores da Colinesterase/farmacologia; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/enzimologia; Animais; Electrophorus; Humanos; Simulação de Acoplamento Molecular; Pirazóis/química; Pirazóis/farmacologia

Palavras-chave

2-Pyrazoline derivatives of chalcones; Alzheimer's disease; Cholinesterases inhibitors; Molecular docking; Piperidyl-thienyl derivatives

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Butirilcolinesterase / Inibidores da Colinesterase / Chalconas Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Paquistão

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