Dehydration of CO2-α-cyclodextrin complex powder by desiccant adsorption method and its release properties.
J Microencapsul
; 33(8): 763-772, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27866448
ABSTRACT
Stability and release properties of CO2-α-cyclodextrin complex powder prepared by solid encapsulation (water activity, aw ≈ 0.95) followed by moisture removal using silica gel and CaCl2 desiccants during post-dehydration were investigated. The results showed that CaCl2 reduced aw much faster than silica gel did under the same conditions. After approximately 60 h, aw of complex powders reduced using silica gel was almost constant at 0.247 (±0.012), while those treated with CaCl2, aw was 0.225 (±0.005) and had not yet reached their lowest value. Moisture adsorption by silica gel and CaCl2 also led to a decrease in the CO2 concentration of complex powder (higher decrease for silica gel adsorption) without affecting the structure and morphology of complex powder. The CO2 release properties of CaCl2-aw-reduced complex powder at different relative humidities (32.73, 52.86, 75.32 and 97.30% RH), liquid environments (water and oil) and packaging methods (normal and vacuum) were also studied.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dióxido de Carbono
/
Alfa-Ciclodextrinas
/
Dessecação
/
Higroscópicos
Idioma:
En
Revista:
J Microencapsul
Assunto da revista:
FARMACIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Austrália