Tryptophan hydroxylase 1 and 5-HT<sub>7</sub> receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.

Gautam, Jaya; Banskota, Suhrid; Regmi, Sushil Chandra; Ahn, Subi; Jeon, Yong Hyun; Jeong, Hyunyoung; Kim, Seung Joo; Nam, Tae-Gyu; Jeong, Byeong-Seon; Kim, Jung-Ae

Tryptophan hydroxylase 1 and 5-HT₇ receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.

Gautam, Jaya; Banskota, Suhrid; Regmi, Sushil Chandra; Ahn, Subi; Jeon, Yong Hyun; Jeong, Hyunyoung; Kim, Seung Joo; Nam, Tae-Gyu; Jeong, Byeong-Seon; Kim, Jung-Ae.

Afiliação

Gautam J; College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 38541, Republic of Korea.
Banskota S; College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 38541, Republic of Korea.
Regmi SC; College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 38541, Republic of Korea.
Ahn S; Department of Nuclear Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Jeon YH; Department of Nuclear Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Jeong H; Departments of Pharmacy Practice and Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Kim SJ; College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 38541, Republic of Korea.
Nam TG; Department of Pharmacy, Hanyang University, Ansan, 15588, Republic of Korea.
Jeong BS; College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 38541, Republic of Korea. jeongb@ynu.ac.kr.
Kim JA; College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 38541, Republic of Korea. jakim@yu.ac.kr.

Mol Cancer ; 15(1): 75, 2016 11 21.

Article em En | MEDLINE | ID: mdl-27871326

Assuntos

Comunicação Autócrina; Receptores de Serotonina/genética; Serotonina/metabolismo; Neoplasias de Mama Triplo Negativas/genética; Neoplasias de Mama Triplo Negativas/metabolismo; Triptofano Hidroxilase/genética; Animais; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; AMP Cíclico/metabolismo; Modelos Animais de Doenças; Progressão da Doença; Feminino; Humanos; Camundongos; Modelos Biológicos; Receptores de Serotonina/metabolismo; Serotonina/farmacologia; Antagonistas da Serotonina/farmacologia; Transdução de Sinais/efeitos dos fármacos; Neoplasias de Mama Triplo Negativas/patologia; Triptofano Hidroxilase/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

5-HT7 receptor; 6-Amino-2,4,5-trimethylpyridin-3-ol; Autocrine 5-HT action; Triple negative breast cancer; Tryptophan hydroxylase 1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triptofano Hidroxilase / Serotonina / Receptores de Serotonina / Comunicação Autócrina / Neoplasias de Mama Triplo Negativas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Mol Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article

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