Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.

Milewicz, Dianna M; Trybus, Kathleen M; Guo, Dong-Chuan; Sweeney, H Lee; Regalado, Ellen; Kamm, Kristine; Stull, James T

Milewicz, Dianna M; Trybus, Kathleen M; Guo, Dong-Chuan; Sweeney, H Lee; Regalado, Ellen; Kamm, Kristine; Stull, James T.

Afiliação

Milewicz DM; From the Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (D.M.M., D.-c.G., E.R.); Department of Molecular Physiology and Biophysics, University of Vermont, Burlington (K.M.T.); Department of Pharmacology and Therapeutics, Universit
Trybus KM; From the Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (D.M.M., D.-c.G., E.R.); Department of Molecular Physiology and Biophysics, University of Vermont, Burlington (K.M.T.); Department of Pharmacology and Therapeutics, Universit
Guo DC; From the Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (D.M.M., D.-c.G., E.R.); Department of Molecular Physiology and Biophysics, University of Vermont, Burlington (K.M.T.); Department of Pharmacology and Therapeutics, Universit
Sweeney HL; From the Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (D.M.M., D.-c.G., E.R.); Department of Molecular Physiology and Biophysics, University of Vermont, Burlington (K.M.T.); Department of Pharmacology and Therapeutics, Universit
Regalado E; From the Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (D.M.M., D.-c.G., E.R.); Department of Molecular Physiology and Biophysics, University of Vermont, Burlington (K.M.T.); Department of Pharmacology and Therapeutics, Universit
Kamm K; From the Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (D.M.M., D.-c.G., E.R.); Department of Molecular Physiology and Biophysics, University of Vermont, Burlington (K.M.T.); Department of Pharmacology and Therapeutics, Universit
Stull JT; From the Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston (D.M.M., D.-c.G., E.R.); Department of Molecular Physiology and Biophysics, University of Vermont, Burlington (K.M.T.); Department of Pharmacology and Therapeutics, Universit

Arterioscler Thromb Vasc Biol ; 37(1): 26-34, 2017 01.

Article em En | MEDLINE | ID: mdl-27879251

Assuntos

Aneurisma da Aorta Torácica/fisiopatologia; Dissecção Aórtica/fisiopatologia; Músculo Liso Vascular/fisiopatologia; Vasoconstrição; Actinas/genética; Actinas/metabolismo; Dissecção Aórtica/genética; Dissecção Aórtica/metabolismo; Dissecção Aórtica/patologia; Animais; Aneurisma da Aorta Torácica/genética; Aneurisma da Aorta Torácica/metabolismo; Aneurisma da Aorta Torácica/patologia; Proteínas de Ligação ao Cálcio/genética; Proteínas de Ligação ao Cálcio/metabolismo; Proteína Quinase Dependente de GMP Cíclico Tipo I/genética; Proteína Quinase Dependente de GMP Cíclico Tipo I/metabolismo; Dilatação Patológica; Elastina/metabolismo; Marcadores Genéticos; Testes Genéticos; Hereditariedade; Humanos; Mecanotransdução Celular; Músculo Liso Vascular/metabolismo; Músculo Liso Vascular/patologia; Mutação; Miócitos de Músculo Liso/metabolismo; Miócitos de Músculo Liso/patologia; Cadeias Pesadas de Miosina/genética; Cadeias Pesadas de Miosina/metabolismo; Quinase de Cadeia Leve de Miosina/genética; Quinase de Cadeia Leve de Miosina/metabolismo; Fenótipo; Fluxo Pulsátil; Vasoconstrição/genética

Palavras-chave

Marfan syndrome; aortic aneurysm; aortic dissection; mutation; thoracic aorta; vascular smooth muscle cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasoconstrição / Aneurisma da Aorta Torácica / Dissecção Aórtica / Músculo Liso Vascular Idioma: En Revista: Arterioscler Thromb Vasc Biol Assunto da revista: ANGIOLOGIA Ano de publicação: 2017 Tipo de documento: Article

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