Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and necrotic cell death in lung cancer.

Rodilla, Ananda M; Korrodi-Gregório, Luís; Hernando, Elsa; Manuel-Manresa, Pilar; Quesada, Roberto; Pérez-Tomás, Ricardo; Soto-Cerrato, Vanessa

Rodilla, Ananda M; Korrodi-Gregório, Luís; Hernando, Elsa; Manuel-Manresa, Pilar; Quesada, Roberto; Pérez-Tomás, Ricardo; Soto-Cerrato, Vanessa.

Afiliação

Rodilla AM; Cancer Cell Biology Research Group, Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona, Barcelona, Spain. Electronic address: ananda.rodilla@ub.edu.
Korrodi-Gregório L; Cancer Cell Biology Research Group, Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Laboratory of Signal Transduction, Department of Medical Sciences, Institute for Research in Biomedicine - iBiMED, Health Sciences Program, Unive
Hernando E; Department of Chemistry, University of Burgos, Burgos, Spain. Electronic address: ehsanta@ubu.es.
Manuel-Manresa P; Cancer Cell Biology Research Group, Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona, Barcelona, Spain. Electronic address: pilarmanuel@ub.edu.
Quesada R; Department of Chemistry, University of Burgos, Burgos, Spain. Electronic address: rquesada@ubu.es.
Pérez-Tomás R; Cancer Cell Biology Research Group, Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona, Barcelona, Spain. Electronic address: rperez@ub.edu.
Soto-Cerrato V; Cancer Cell Biology Research Group, Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona, Barcelona, Spain. Electronic address: vsoto@ub.edu.

Biochem Pharmacol ; 126: 23-33, 2017 Feb 15.

Article em En | MEDLINE | ID: mdl-27890727

Assuntos

Alcaloides/farmacologia; Antineoplásicos/farmacologia; Autofagia/efeitos dos fármacos; Ionóforos/farmacologia; Lisossomos/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Pirróis/farmacologia; Alcaloides/síntese química; Antineoplásicos/síntese química; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Humanos; Concentração de Íons de Hidrogênio; Lisossomos/metabolismo; Mitocôndrias/patologia; Tamanho Mitocondrial; Necrose; Células-Tronco Neoplásicas/efeitos dos fármacos; Células-Tronco Neoplásicas/patologia; Pirróis/síntese química

Palavras-chave

Anionophores; Autophagy blockade; Lysosomal dysfunction; Necrosis; Synthetic tambjamine analogues

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirróis / Autofagia / Alcaloides / Ionóforos / Lisossomos / Mitocôndrias / Antineoplásicos Limite: Humans Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2017 Tipo de documento: Article

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