Importance of 5/6-aryl substitution on the pharmacological profile of 4'-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid derived PPARÎ³ agonists.

Obermoser, Victoria; Mauersberger, Robert; Schuster, Daniela; Czifersky, Monika; Lipova, Marina; Siegl, Monika; Kintscher, Ulrich; Gust, Ronald

Obermoser, Victoria; Mauersberger, Robert; Schuster, Daniela; Czifersky, Monika; Lipova, Marina; Siegl, Monika; Kintscher, Ulrich; Gust, Ronald.

Afiliação

Obermoser V; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria.
Mauersberger R; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria.
Schuster D; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria.
Czifersky M; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria.
Lipova M; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria.
Siegl M; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria.
Kintscher U; Institute of Pharmacology, Center for Cardiovascular Research, Charité Universitätsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany.
Gust R; Department of Pharmaceutical Chemistry, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria. Electronic address: Ronald.Gust@uibk.ac.at.

Eur J Med Chem ; 126: 590-603, 2017 Jan 27.

Article em En | MEDLINE | ID: mdl-27918994

Assuntos

Benzimidazóis/farmacologia; Benzoatos/farmacologia; PPAR gama/agonistas; Benzimidazóis/química; Humanos; Modelos Moleculares; Correpressor 1 de Receptor Nuclear/efeitos dos fármacos; Correpressor 1 de Receptor Nuclear/metabolismo; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Ligação Proteica; Relação Estrutura-Atividade; Telmisartan

Palavras-chave

Coactivator recruitment; Molecular modeling; Peroxisome proliferator-activated receptor Î³; Pharmacological profile; Transactivation assay

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Benzoatos / PPAR gama Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Áustria

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