ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.

Williamson, Chris T; Miller, Rowan; Pemberton, Helen N; Jones, Samuel E; Campbell, James; Konde, Asha; Badham, Nicholas; Rafiq, Rumana; Brough, Rachel; Gulati, Aditi; Ryan, Colm J; Francis, Jeff; Vermulen, Peter B; Reynolds, Andrew R; Reaper, Philip M; Pollard, John R; Ashworth, Alan; Lord, Christopher J

Williamson, Chris T; Miller, Rowan; Pemberton, Helen N; Jones, Samuel E; Campbell, James; Konde, Asha; Badham, Nicholas; Rafiq, Rumana; Brough, Rachel; Gulati, Aditi; Ryan, Colm J; Francis, Jeff; Vermulen, Peter B; Reynolds, Andrew R; Reaper, Philip M; Pollard, John R; Ashworth, Alan; Lord, Christopher J.

Afiliação

Williamson CT; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.
Miller R; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Pemberton HN; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.
Jones SE; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Campbell J; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.
Konde A; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Badham N; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.
Rafiq R; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Brough R; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.
Gulati A; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Ryan CJ; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.
Francis J; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Vermulen PB; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.
Reynolds AR; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Reaper PM; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.
Pollard JR; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
Ashworth A; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London SW3 6JB, UK.
Lord CJ; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

Nat Commun ; 7: 13837, 2016 12 13.

Article em En | MEDLINE | ID: mdl-27958275

Assuntos

Pontos de Checagem do Ciclo Celular/genética; Proteínas Nucleares/genética; Fatores de Transcrição/genética; Antineoplásicos/farmacologia; Apoptose; Proteínas Mutadas de Ataxia Telangiectasia/antagonistas & inibidores; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proteínas de Ligação a DNA; Humanos; Interferência de RNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Pontos de Checagem do Ciclo Celular Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido

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