Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia.
Learn Mem
; 24(1): 59-64, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-27980077
ABSTRACT
We investigated the in vivo role of protein degradation during intermediate (ITM) and long-term memory (LTM) in Aplysia using an operant learning paradigm. The proteasome inhibitor MG-132 inhibited the induction and molecular consolidation of LTM with no effect on ITM. Remarkably, maintenance of steady-state protein levels through inhibition of protein synthesis using either anisomycin or rapamycin in conjunction with proteasome inhibition permitted the formation of robust 24 h LTM. Our studies suggest a primary role for proteasomal activity in facilitation of gene transcription for LTM and raise the possibility that synaptic mechanisms are sufficient to sustain 24 h memory.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aplysia
/
Condicionamento Operante
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Complexo de Endopeptidases do Proteassoma
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Memória de Longo Prazo
Limite:
Animals
Idioma:
En
Revista:
Learn Mem
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos