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In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress.
Jones, Crystal L; Singh, Shweta S; Alamneh, Yonas; Casella, Leila G; Ernst, Robert K; Lesho, Emil P; Waterman, Paige E; Zurawski, Daniel V.
Afiliação
  • Jones CL; Wound Infections Department, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA dr.crystaljones@gmail.com.
  • Singh SS; Wound Infections Department, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
  • Alamneh Y; Wound Infections Department, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
  • Casella LG; Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, Maryland, USA.
  • Ernst RK; Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, Maryland, USA.
  • Lesho EP; Multidrug-resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
  • Waterman PE; Multidrug-resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
  • Zurawski DV; Wound Infections Department, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Antimicrob Agents Chemother ; 61(3)2017 03.
Article em En | MEDLINE | ID: mdl-27993849
ABSTRACT
The loss of fitness in colistin-resistant (CR) Acinetobacter baumannii was investigated using longitudinal isolates from the same patient. Early CR isolates were outcompeted by late CR isolates for growth in broth and survival in the lungs of mice. Fitness loss was associated with an increased susceptibility to oxidative stress since early CR strains had reduced in vitro survival in the presence of hydrogen peroxide and decreased catalase activity compared to that of late CR and colistin-susceptible (CS) strains.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adaptação Fisiológica / Colistina / Farmacorresistência Bacteriana / Acinetobacter baumannii / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adaptação Fisiológica / Colistina / Farmacorresistência Bacteriana / Acinetobacter baumannii / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos