Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis.
Gastroenterology
; 152(3): 533-545, 2017 02.
Article
em En
| MEDLINE
| ID: mdl-28003097
ABSTRACT
The Hippo signaling pathway, also known as the Salvador-Warts-Hippo pathway, is a regulator of organ size. The pathway takes its name from the Drosophila protein kinase, Hippo (STK4/MST1 and STK3/MST2 in mammals), which, when inactivated, leads to considerable tissue overgrowth. In mammals, MST1 and MST2 negatively regulate the transcriptional co-activators yes-associated protein 1 and WW domain containing transcription regulator 1 (WWTR1/TAZ), which together regulate expression of genes that control proliferation, survival, and differentiation. Yes-associated protein 1 and TAZ activation have been associated with liver development, regeneration, and tumorigenesis. How their activity is dynamically regulated in these contexts is just beginning to be elucidated. We review the mechanisms of Hippo signaling in the liver and explore outstanding questions for future research.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
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Fatores de Transcrição
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Proteínas Serina-Treonina Quinases
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Carcinoma Hepatocelular
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Peptídeos e Proteínas de Sinalização Intracelular
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Proteínas Adaptadoras de Transdução de Sinal
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Fígado
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Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Revista:
Gastroenterology
Ano de publicação:
2017
Tipo de documento:
Article