Mildly Acidic pH Triggers an Irreversible Conformational Change in the Fusion Domain of Herpes Simplex Virus 1 Glycoprotein B and Inactivation of Viral Entry.

Weed, Darin J; Pritchard, Suzanne M; Gonzalez, Floricel; Aguilar, Hector C; Nicola, Anthony V

Weed, Darin J; Pritchard, Suzanne M; Gonzalez, Floricel; Aguilar, Hector C; Nicola, Anthony V.

Afiliação

Weed DJ; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
Pritchard SM; Protein Biotechnology Graduate Training Program, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
Gonzalez F; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
Aguilar HC; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
Nicola AV; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.

J Virol ; 91(5)2017 03 01.

Article em En | MEDLINE | ID: mdl-28003487

Assuntos

Herpes Simples/virologia; Herpesvirus Humano 1/fisiologia; Proteínas do Envelope Viral/química; Animais; Chlorocebus aethiops; Concentração de Íons de Hidrogênio; Domínios Proteicos; Células Vero; Proteínas do Envelope Viral/fisiologia; Ligação Viral; Internalização do Vírus

Palavras-chave

conformational changes; glycoprotein B; herpes simplex viruses; herpesviruses; inactivation; low pH; membrane fusion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Herpesvirus Humano 1 / Herpes Simples Limite: Animals Idioma: En Revista: J Virol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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