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Anal verrucous carcinoma is not related to infection with human papillomaviruses and should be distinguished from giant condyloma (Buschke-Löwenstein tumour).
Zidar, Nina; Langner, Cord; Odar, Katarina; Hosnjak, Lea; Kamarádová, Katerina; Daum, Ondrej; Pollheimer, Marion J; Kosorok, Pavle; Poljak, Mario.
Afiliação
  • Zidar N; Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Langner C; Institute of Pathology, Medical University of Graz, Graz, Austria.
  • Odar K; Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Hosnjak L; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Kamarádová K; University Hospital in Hradec Kralove, Hradec Králové, Czech Republic.
  • Daum O; Sikl's Department of Pathology, Medical Faculty Hospital, Charles University, Pilsen, Czech Republic.
  • Pollheimer MJ; Institute of Pathology, Medical University of Graz, Graz, Austria.
  • Kosorok P; Medical Centre IATROS, Ljubljana, Slovenia.
  • Poljak M; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Histopathology ; 70(6): 938-945, 2017 May.
Article em En | MEDLINE | ID: mdl-28012208
ABSTRACT

AIMS:

Verrucous carcinoma (VC) is a variant of well-differentiated squamous cell carcinoma and in the anal region is regarded as synonymous with giant condyloma (Buschke-Löwenstein tumour) (BLT). Aetiology, diagnostic criteria and clinical behaviour of both lesions are controversial. Recent studies suggest that VC at other sites is not associated with human papillomaviruses (HPV). We hypothesized that anal VC is also not related to HPV, while BLT is a HPV-induced lesion. METHODS AND

RESULTS:

Ten cases of VC and four cases of BLT were included. Several techniques were used for HPV detection in-situ hybridization for HPV6, 11, 16 and 18, six different polymerase chain reaction (PCR) protocols for detection of at least 89 HPV types from alpha-, beta-, gamma- and mu-PV genera and in-situ hybridization for high-risk HPV E6/E7 mRNA; p16 immunohistochemistry and morphometric analysis were also performed. Alpha-, gamma- and mu-PVs were not found in any case of VC, while HPV6 was detected in all cases of BLT. p16 overexpression was not present in any of the lesions. Among microscopic features, only the absence of koilocytosis and enlarged spinous cells seem to be useful to distinguish VC from BLT.

CONCLUSIONS:

Our results suggest that anal VC, similarly to VC at other sites, is not associated with HPV infection, and must be distinguished from BLT, which is associated with low-risk HPV. Only with well-set diagnostic criteria will it be possible to ascertain clinical behaviour and optimal treatment for both lesions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Ânus / Carcinoma Verrucoso / Tumor de Buschke-Lowenstein Tipo de estudo: Guideline Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Histopathology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Eslovênia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Ânus / Carcinoma Verrucoso / Tumor de Buschke-Lowenstein Tipo de estudo: Guideline Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Histopathology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Eslovênia