Topical ivermectin improves allergic skin inflammation.
Allergy
; 72(8): 1212-1221, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28052336
ABSTRACT
BACKGROUND:
Ivermectin (IVM) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested that IVM could also have anti-inflammatory properties.METHODS:
Here, we investigated the activity of IVM in a murine model of atopic dermatitis (AD) induced by repeated exposure to the allergen Dermatophagoides farinae, and in standard cellular immunological assays.RESULTS:
Our results show that topical IVM improved allergic skin inflammation by reducing the priming and activation of allergen-specific T cells, as well as the production of inflammatory cytokines. While IVM had no major impact on the functions of dendritic cells in vivo and in vitro, IVM impaired T-cell activation, proliferation, and cytokine production following polyclonal and antigen-specific stimulation.CONCLUSION:
Altogether, our results show that IVM is endowed with topical anti-inflammatory properties that could have important applications for the treatment of T-cell-mediated skin inflammatory diseases.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ivermectina
/
Alérgenos
/
Dermatite Atópica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Allergy
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
França