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Prophage-mediated defence against viral attack and viral counter-defence.
Dedrick, Rebekah M; Jacobs-Sera, Deborah; Bustamante, Carlos A Guerrero; Garlena, Rebecca A; Mavrich, Travis N; Pope, Welkin H; Reyes, Juan C Cervantes; Russell, Daniel A; Adair, Tamarah; Alvey, Richard; Bonilla, J Alfred; Bricker, Jerald S; Brown, Bryony R; Byrnes, Deanna; Cresawn, Steven G; Davis, William B; Dickson, Leon A; Edgington, Nicholas P; Findley, Ann M; Golebiewska, Urszula; Grose, Julianne H; Hayes, Cory F; Hughes, Lee E; Hutchison, Keith W; Isern, Sharon; Johnson, Allison A; Kenna, Margaret A; Klyczek, Karen K; Mageeney, Catherine M; Michael, Scott F; Molloy, Sally D; Montgomery, Matthew T; Neitzel, James; Page, Shallee T; Pizzorno, Marie C; Poxleitner, Marianne K; Rinehart, Claire A; Robinson, Courtney J; Rubin, Michael R; Teyim, Joseph N; Vazquez, Edwin; Ware, Vassie C; Washington, Jacqueline; Hatfull, Graham F.
Afiliação
  • Dedrick RM; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Jacobs-Sera D; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Bustamante CA; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Garlena RA; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Mavrich TN; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Pope WH; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Reyes JC; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Russell DA; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Adair T; Department of Biology, Baylor University, Waco, Texas 76798, USA.
  • Alvey R; Biology Department, Illinois-Wesleyan University, Bloomington, Illinois 61702, USA.
  • Bonilla JA; Biology Department, University of Wisconsin-River Falls, River Falls, Wisconsin 54016, USA.
  • Bricker JS; Biology Department, Nebraska-Wesleyan University, Lincoln, Nebraska 68504, USA.
  • Brown BR; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Byrnes D; Biology Department, Carthage College, Kenosha, Wisconsin 53140, USA.
  • Cresawn SG; Biology Department, James Madison University, Harrisonburg, Virginia 22807, USA.
  • Davis WB; School of Molecular Biosciences, Washington State University Pullman, Washington 99164, USA.
  • Dickson LA; Department of Biology, Howard University, Washington, Washington DC 20059, USA.
  • Edgington NP; Biology Department, Southern Connecticut State University, New Haven, Connecticut 06515, USA.
  • Findley AM; Biology, School of Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA.
  • Golebiewska U; Biological Sciences and Geology, Queensborough Community College, Bayside, New York 11364, USA.
  • Grose JH; Biology Department, Brigham Young University, Provo, Utah 84602, USA.
  • Hayes CF; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Hughes LE; Biological Sciences, University of North Texas, Denton, Texas 76203, USA.
  • Hutchison KW; Molecular and Biomedical Sciences, University of Maine, Honors College, Orono, Maine 04469, USA.
  • Isern S; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
  • Johnson AA; Biology Department, Virginia Commonwealth University, Richmond, Virginia 23284, USA.
  • Kenna MA; Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
  • Klyczek KK; Biology Department, University of Wisconsin-River Falls, River Falls, Wisconsin 54016, USA.
  • Mageeney CM; Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
  • Michael SF; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
  • Molloy SD; Molecular and Biomedical Sciences, University of Maine, Honors College, Orono, Maine 04469, USA.
  • Montgomery MT; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
  • Neitzel J; Biology Department, The Evergreen State College, Olympia, Washington 98502, USA.
  • Page ST; Division of Environmental and Biological Sciences, University of Maine-Machias, Machias, Maine 04654, USA.
  • Pizzorno MC; Biology Department, Bucknell University, Lewisburg, Pennsylvania 17837, USA.
  • Poxleitner MK; Biology Department, Gonzaga University, Spokane, Washington 99258, USA.
  • Rinehart CA; Biology Department, Western Kentucky University, Bowling Green, Kentucky 42101, USA.
  • Robinson CJ; Department of Biology, Howard University, Washington, Washington DC 20059, USA.
  • Rubin MR; Biology Department, University of Puerto Rico-Cayey, Cayey, Puerto Rico 00736, USA.
  • Teyim JN; Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
  • Vazquez E; Biology Department, University of Puerto Rico-Cayey, Cayey, Puerto Rico 00736, USA.
  • Ware VC; Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
  • Washington J; Department of Biology and Chemistry, Nyack College, Nyack, New York 10960, USA.
  • Hatfull GF; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Nat Microbiol ; 2: 16251, 2017 Jan 09.
Article em En | MEDLINE | ID: mdl-28067906
Temperate phages are common, and prophages are abundant residents of sequenced bacterial genomes. Mycobacteriophages are viruses that infect mycobacterial hosts including Mycobacterium tuberculosis and Mycobacterium smegmatis, encompass substantial genetic diversity and are commonly temperate. Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct prophage-expressed viral defence systems that interfere with the infection of lytic and temperate phages that are either closely related (homotypic defence) or unrelated (heterotypic defence) to the prophage. Target specificity is unpredictable, ranging from a single target phage to one-third of those tested. The defence systems include a single-subunit restriction system, a heterotypic exclusion system and a predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes bacterial survival and enables efficient lysogeny. The predicted (p)ppGpp synthetase coded by the Phrann prophage defends against phage Tweety infection, but Tweety codes for a tetrapeptide repeat protein, gp54, which acts as a highly effective counter-defence system. Prophage-mediated viral defence offers an efficient mechanism for bacterial success in host-virus dynamics, and counter-defence promotes phage co-evolution.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium smegmatis / Prófagos / Micobacteriófagos / Mycobacterium tuberculosis Idioma: En Revista: Nat Microbiol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium smegmatis / Prófagos / Micobacteriófagos / Mycobacterium tuberculosis Idioma: En Revista: Nat Microbiol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos