Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment.
BBA Clin
; 7: 41-54, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28070499
ABSTRACT
BACKGROUND:
Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D) has been well established. Cyclo(His-Pro) plus zinc (Cyclo-Z) treatment ameliorated diabetes in rats and similar improvements have been seen in human patients. Treatment of amyloid precursor protein (APP) transgenic mice with Cyclo-Z exhibited memory improvements and significantly reduced Aß-40 and Aß-42 protein levels in the brain tissues of the mice. SCOPE OF REVIEW Metabolic relationship between AD and T2D will be described with particular attention to insulin sensitivity and Aß degradation in brain and plasma tissues. Mechanistic effect of insulin degrading enzyme (IDE) in decreasing blood glucose and brain Aß levels will be elucidated. Cyclo-Z effects on these biochemical parameters will be discussed. MAJORCONCLUSION:
Stimulation of IDE synthesis is effective for the clinical treatment of metabolic diseases including AD and T2D. GENERALSIGNIFICANCE:
Cyclo-Z might be the effective treatment of AD and T2D by stimulating IDE synthesis.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
BBA Clin
Ano de publicação:
2017
Tipo de documento:
Article