Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces.
J R Soc Interface
; 14(126)2017 01.
Article
em En
| MEDLINE
| ID: mdl-28077764
ABSTRACT
The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material-tissue interface with an antimicrobial peptide (AMP) coating to allow cell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists of AMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs. The dual approach gives an efficacious coating which is stable for over 12 months and can prevent colonization of the surface by both Gram-positive and Gram-negative bacteria.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
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Teste de Materiais
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Durapatita
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Materiais Revestidos Biocompatíveis
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Peptídeos Catiônicos Antimicrobianos
Limite:
Animals
Idioma:
En
Revista:
J R Soc Interface
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido