Receptor tyrosine kinase inhibition by regorafenib/sorafenib inhibits growth and invasion of meningioma cells.

Tuchen, Marcus; Wilisch-Neumann, Annette; Daniel, Evelyn A; Baldauf, Lisa; Pachow, Doreen; Scholz, Johannes; Angenstein, Frank; Stork, Oliver; Kirches, Elmar; Mawrin, Christian

Tuchen, Marcus; Wilisch-Neumann, Annette; Daniel, Evelyn A; Baldauf, Lisa; Pachow, Doreen; Scholz, Johannes; Angenstein, Frank; Stork, Oliver; Kirches, Elmar; Mawrin, Christian.

Afiliação

Tuchen M; Department of Neuropathology & Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany.
Wilisch-Neumann A; Department of Neuropathology & Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany.
Daniel EA; Department of Neuropathology & Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany.
Baldauf L; Department of Neuropathology & Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany.
Pachow D; Department of Neuropathology & Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany.
Scholz J; Department of Neuropathology & Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany.
Angenstein F; DZNE, Department for Genetics & Molecular Neurobiology, Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany.
Stork O; Institute of Biology, Department for Genetics & Molecular Neurobiology, Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany.
Kirches E; Department of Neuropathology & Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany.
Mawrin C; Department of Neuropathology & Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg, and Center of Behavioral Brain Science, Magdeburg, Germany. Electronic address: christian.mawrin@med.ovgu.de.

Eur J Cancer ; 73: 9-21, 2017 03.

Article em En | MEDLINE | ID: mdl-28082204

Assuntos

Neoplasias Meníngeas/tratamento farmacológico; Meningioma/tratamento farmacológico; Niacinamida/análogos & derivados; Compostos de Fenilureia/uso terapêutico; Inibidores de Proteínas Quinases/uso terapêutico; Piridinas/uso terapêutico; Animais; Apoptose/efeitos dos fármacos; Western Blotting; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Depsipeptídeos; Modelos Animais de Doenças; Humanos; Neoplasias Meníngeas/patologia; Meningioma/patologia; Camundongos; Invasividade Neoplásica; Niacinamida/farmacologia; Niacinamida/uso terapêutico; Compostos de Fenilureia/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Piridinas/farmacologia; Transdução de Sinais/efeitos dos fármacos; Sorafenibe; Células Tumorais Cultivadas

Palavras-chave

Meningioma; PDGF receptor; Regorafenib; Sorafenib; Survival

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Piridinas / Niacinamida / Inibidores de Proteínas Quinases / Neoplasias Meníngeas / Meningioma Limite: Animals / Humans Idioma: En Revista: Eur J Cancer Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha

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