[The clinical features of patients with lymphoplasmacytic diseases harboring MyD88 L265P mutation].
Zhonghua Xue Ye Xue Za Zhi
; 37(12): 1054-1059, 2016 Dec 14.
Article
em Zh
| MEDLINE
| ID: mdl-28088969
ABSTRACT
Objective:
To explore the clinical features of lymphoplasmacytic diseases with MyD88 L265P mutation.Methods:
To analyze the distribution of MYD88 L265P mutation in patients with lymphoplasmacytic diseases by using of ARMS PCR-CE.Results:
There were 25(30.9%) MyD88 L265P mutated patients in 81 patients. The mutation was frequently observed in 14 patients with WM (77.8%, 14/18), 2 patients with lymphoplasmacytic lymphoma (66.7%, 2/3), 1 acute lymphocytic leukemia patient (50.0%, 1/2), 3 multiple myeloma patients (30.0%, 3/10), 1 patient with monoclonal gammopathy of undetermined significance (25%, 1/4), 3 patients with chronic lymphocytic leukemia (13.0%, 3/23) and 1 lymphoma patient (4.8%, 1/21). 20 (80%, 20/25) patients were identified with IgM subtype. Compared with wild-type group of 56 cases, mutated patients were older (median age 67 years vs 55 years, P< 0.001), with lower WBC count (median count 5.23 × 109/L vs 10.80 × 109/L, P=0.001), lower HGB level (median count 85 g/L vs 119 g/L, P<0.001).Conclusion:
MyD88 L265P mutation was mainly observed in patients with IgM subtype lymphoplasmacytic diseases, and Waldenstrom' s macroglobulinemia was the most common disease. Compared with the wild-type group, patients with MyD88 L265P mutation were older and had lower WBC count, lower level of HGB. However, further studies were needed to test the prognostic value of MyD88 L265P mutation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Macroglobulinemia de Waldenstrom
/
Fator 88 de Diferenciação Mieloide
/
Mieloma Múltiplo
/
Mutação
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Zhonghua Xue Ye Xue Za Zhi
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China