Diabetes is Associated with Severe Adverse Events in Multidrug-Resistant Tuberculosis. / La diabetes se asocia con reacciones adversas graves en la tuberculosis multirresistente.
Arch Bronconeumol
; 53(5): 245-250, 2017 May.
Article
em En, Es
| MEDLINE
| ID: mdl-28089216
ABSTRACT
INTRODUCTION:
Diabetes mellitus (DM), a very common disease in Mexico, is a well-known risk factor for tuberculosis (TB). However, it is not known by which extent DM predisposes to adverse events (AE) to anti-TB drugs and/or to worse outcomes in patients with multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). The main objective of this study was to describe the outcomes of TB treatment, the impact of DM and the prevalence of AE in a cohort of patients with MDR-/XDR pulmonary TB treated at the national TB referral centre in Mexico City.RESULTS:
Ninety patients were enrolled between 2010 and 2015 73 with MDR-TB (81.1%), 11 with pre-XDR-TB (12.2%) and 6 (6.7%) with XDR-TB, including 49 (54.4%) with DM, and 3 with Human Immunodeficiency Virus (HIV) co-infection (3.3%). In 98% of patients, diagnosis was made by culture and drug susceptibility testing, while in a single case the diagnosis was made by a molecular test. The presence of DM was associated with an increased risk of serious drug-related AEs, such as nephrotoxicity (Odds Ratio [OR]=6.5; 95% Confidence Interval [95% CI] 1.9-21.8) and hypothyroidism (OR=8.8; 95% CI 1.8-54.2), but not for a worse outcome.CONCLUSIONS:
Our data suggest that DM does not impact second-line TB treatment outcomes, but patients with DM have a higher risk of developing serious AEs to drug-resistant TB treatment, such as nephrotoxicity and hypothyroidism.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Tuberculose Resistente a Múltiplos Medicamentos
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Diabetes Mellitus Tipo 2
/
Antituberculosos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Mexico
Idioma:
En
/
Es
Revista:
Arch Bronconeumol
Ano de publicação:
2017
Tipo de documento:
Article