miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks.

Hu, Baocheng; Wang, Xiang; Hu, Shuofeng; Ying, Xiaomin; Wang, Ping; Zhang, Xiangming; Wang, Jian; Wang, Hongyan; Wang, Ya

Hu, Baocheng; Wang, Xiang; Hu, Shuofeng; Ying, Xiaomin; Wang, Ping; Zhang, Xiangming; Wang, Jian; Wang, Hongyan; Wang, Ya.

Afiliação

Hu B; Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322.
Wang X; Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322.
Hu S; Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Ying X; Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Wang P; Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322.
Zhang X; Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322.
Wang J; Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322.
Wang H; Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322.
Wang Y; Department of Radiation Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322. Electronic address: ywang94@emory.edu.

J Biol Chem ; 292(8): 3531-3540, 2017 02 24.

Article em En | MEDLINE | ID: mdl-28096467

Assuntos

Quebras de DNA de Cadeia Dupla; Reparo do DNA; Regulação da Expressão Gênica; MicroRNAs/genética; Animais; Linhagem Celular; Quebras de DNA de Cadeia Dupla/efeitos da radiação; Reparo do DNA por Junção de Extremidades/efeitos da radiação; Reparo do DNA/efeitos da radiação; Regulação da Expressão Gênica/efeitos da radiação; Glicogênio Sintase Quinase 3 beta/genética; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Neoplasias/genética; Tolerância a Radiação; Reparo de DNA por Recombinação/efeitos da radiação

Palavras-chave

DNA double strand breaks; DNA repair; DNA-dependent serine/threonine protein kinase (DNA-PK); GSK3ß; cellular regulation; homologous recombination repair; ionizing radiation; miR-21; microRNA (miRNA); non-homologous end-joining; radiation biology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / MicroRNAs / Reparo do DNA / Quebras de DNA de Cadeia Dupla Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article

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