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Novel genetic loci associated with hippocampal volume.
Hibar, Derrek P; Adams, Hieab H H; Jahanshad, Neda; Chauhan, Ganesh; Stein, Jason L; Hofer, Edith; Renteria, Miguel E; Bis, Joshua C; Arias-Vasquez, Alejandro; Ikram, M Kamran; Desrivières, Sylvane; Vernooij, Meike W; Abramovic, Lucija; Alhusaini, Saud; Amin, Najaf; Andersson, Micael; Arfanakis, Konstantinos; Aribisala, Benjamin S; Armstrong, Nicola J; Athanasiu, Lavinia; Axelsson, Tomas; Beecham, Ashley H; Beiser, Alexa; Bernard, Manon; Blanton, Susan H; Bohlken, Marc M; Boks, Marco P; Bralten, Janita; Brickman, Adam M; Carmichael, Owen; Chakravarty, M Mallar; Chen, Qiang; Ching, Christopher R K; Chouraki, Vincent; Cuellar-Partida, Gabriel; Crivello, Fabrice; Den Braber, Anouk; Doan, Nhat Trung; Ehrlich, Stefan; Giddaluru, Sudheer; Goldman, Aaron L; Gottesman, Rebecca F; Grimm, Oliver; Griswold, Michael E; Guadalupe, Tulio; Gutman, Boris A; Hass, Johanna; Haukvik, Unn K; Hoehn, David; Holmes, Avram J.
Afiliação
  • Hibar DP; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
  • Adams HHH; Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
  • Jahanshad N; Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.
  • Chauhan G; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
  • Stein JL; INSERM Unit U1219, University of Bordeaux, 33076 Bordeaux, France.
  • Hofer E; Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California 90292, USA.
  • Renteria ME; Department of Genetics & UNC Neuroscience Center, University of North Carolina (UNC), Chapel Hill, North Carolina, 27599, USA.
  • Bis JC; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
  • Arias-Vasquez A; Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
  • Ikram MK; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Desrivières S; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 1730 Minor Avenue/Suite 1360. Seattle, Washington 98101, USA.
  • Vernooij MW; Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  • Abramovic L; Department of Psychiatry, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  • Alhusaini S; Department of Cognitive Neuroscience, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
  • Amin N; Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GA Nijmegen, The Netherlands.
  • Andersson M; Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
  • Arfanakis K; Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore.
  • Aribisala BS; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
  • Armstrong NJ; Memory Aging & Cognition Centre (MACC), National University Health System, Singapore, 119228, Singapore.
  • Athanasiu L; Department of Pharmacology, National University of Singapore, Singapore, 119077, Singapore.
  • Axelsson T; MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
  • Beecham AH; Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
  • Beiser A; Department of Radiology and Nuclear Medicine, Erasmus MC, 3015 CE Rotterdam, The Netherlands.
  • Bernard M; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
  • Blanton SH; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4.
  • Bohlken MM; The Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
  • Boks MP; Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
  • Bralten J; Department of Integrative Medical Biology and Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden.
  • Brickman AM; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois 60616, USA.
  • Carmichael O; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
  • Chakravarty MM; Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, Illinois 60616, USA.
  • Chen Q; Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Ching CRK; Department of Computer Science, Lagos State University, Lagos, P.M.B. 01 LASU, Nigeria.
  • Chouraki V; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Cuellar-Partida G; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales 2052, Australia.
  • Crivello F; Mathematics and Statistics, Murdoch University, Perth, Western Australia, 6150, Australia.
  • Den Braber A; NORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway.
  • Doan NT; NORMENT-KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, 0424 Oslo, Norway.
  • Ehrlich S; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Box 1432, SE-751 44 Uppsala, Sweden.
  • Giddaluru S; Dr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
  • Goldman AL; John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
  • Gottesman RF; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts,02118, USA.
  • Grimm O; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118 USA.
  • Griswold ME; Framingham Heart Study, 17 Mount Wayte Avenue, Framingham, Massachusetts 01703 USA.
  • Guadalupe T; Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8.
  • Gutman BA; Dr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
  • Hass J; John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, 33136, USA.
  • Haukvik UK; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
  • Hoehn D; Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, 3584 CX Utrecht, The Netherlands.
  • Holmes AJ; Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Nat Commun ; 8: 13624, 2017 01 18.
Article em En | MEDLINE | ID: mdl-28098162
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipocampo Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipocampo Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos