Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-&#954;B inhibition and AMPK activation.

Pongkorpsakol, Pawin; Satitsri, Saravut; Wongkrasant, Preedajit; Chittavanich, Pamorn; Kittayaruksakul, Suticha; Srimanote, Potjanee; Chatsudthipong, Varanuj; Muanprasat, Chatchai

Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation.

Pongkorpsakol, Pawin; Satitsri, Saravut; Wongkrasant, Preedajit; Chittavanich, Pamorn; Kittayaruksakul, Suticha; Srimanote, Potjanee; Chatsudthipong, Varanuj; Muanprasat, Chatchai.

Afiliação

Pongkorpsakol P; Graduate Program in Translational Medicine, Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.
Satitsri S; Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.
Wongkrasant P; Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.
Chittavanich P; Department of Pharmacology, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.
Kittayaruksakul S; Department of Basic Medical Science, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Thailand.
Srimanote P; Graduate Studies, Faculty of Allied Health Science, Thammasat University, Paholyothin Road, Rangsit, Prathumthani 12120, Thailand.
Chatsudthipong V; Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand.
Muanprasat C; Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand; Excellent Center for Drug Discovery, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400, Thailand. Electronic address: chatchai.mua@mahidol.ac.th.

Eur J Pharmacol ; 798: 94-104, 2017 Mar 05.

Article em En | MEDLINE | ID: mdl-28119077

Assuntos

Proteínas Quinases Ativadas por AMP/metabolismo; Líquidos Corporais/metabolismo; Cólera/tratamento farmacológico; Ácido Flufenâmico/farmacologia; Intestinos/efeitos dos fármacos; NF-kappa B/antagonistas & inibidores; Vibrio cholerae/fisiologia; Animais; Líquidos Corporais/efeitos dos fármacos; Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina/química; Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina/metabolismo; Domínio Catalítico; Linhagem Celular; Cólera/enzimologia; Cólera/metabolismo; Diarreia/tratamento farmacológico; Diarreia/virologia; Modelos Animais de Doenças; Ácido Flufenâmico/metabolismo; Ácido Flufenâmico/uso terapêutico; Mucosa Intestinal/efeitos dos fármacos; Mucosa Intestinal/metabolismo; Mucosa Intestinal/patologia; Camundongos; Simulação de Acoplamento Molecular

Palavras-chave

AMP-activated protein kinase; Cholera; Flufenamic acid; Inflammation; Vibrio cholerae

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vibrio cholerae / Líquidos Corporais / Ácido Flufenâmico / Cólera / NF-kappa B / Proteínas Quinases Ativadas por AMP / Intestinos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Tailândia

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