Association study between the neurexin-1 gene and tardive dyskinesia.
Hum Psychopharmacol
; 32(1)2017 01.
Article
em En
| MEDLINE
| ID: mdl-28120489
ABSTRACT
OBJECTIVE:
Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication.METHODS:
This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry.RESULTS:
We did not find these SNPs to be significantly associated with TD.CONCLUSIONS:
More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Antipsicóticos
/
Moléculas de Adesão Celular Neuronais
/
Polimorfismo de Nucleotídeo Único
/
Estudos de Associação Genética
/
Discinesia Tardia
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Hum Psychopharmacol
Assunto da revista:
PSICOFARMACOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Canadá