A fermented milk concentrate and a combination of short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides/pectin-derived acidic oligosaccharides protect suckling rats from rotavirus gastroenteritis.
Br J Nutr
; 117(2): 209-217, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-28166850
ABSTRACT
Human milk contains bioactive compounds that confer a protective role against gastrointestinal infections. In order to find supplements for an infant formula able to mimic these benefits of breast-feeding, two different concepts were tested. The products consisted of the following (1) a Bifidobacterium breve- and Streptococcus thermophilus-fermented formula and (2) a combination of short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides with pectin-derived acidic oligosaccharides. A rotavirus infection suckling rat model was used to evaluate improvements in the infectious process and in the immune response of supplemented animals. Both nutritional concepts caused amelioration of the clinical symptoms, even though this was sometimes hidden by softer stool consistency in the supplemented groups. Both products also showed certain modulation of immune response, which seemed to be enhanced earlier and was accompanied by a faster resolution of the process. The viral shedding and the in vitro blocking assay suggest that these products are able to bind the viral particles, which can result in a milder infection. In conclusion, both concepts evaluated in this study showed interesting protective properties against rotavirus infection, which deserve to be investigated further.
Palavras-chave
FM fermented milk; GFA scGOS/lcFOS/pAOS mixture; REF reference; RV rotavirus; lcFOS long-chain fructo-oligosaccharides; pAOS pectin-derived acidic oligosaccharides; scGOS short-chain galacto-oligosaccharides; Fermented formula; Fructo-oligosaccharides; Galacto-oligosaccharides; Milk; Pectin-derived acidic oligosaccharides; Prebiotics; Rotavirus
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Infecções por Rotavirus
/
Bactérias
/
Aleitamento Materno
/
Leite
/
Fermentação
/
Gastroenterite
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
/
Infant
Idioma:
En
Revista:
Br J Nutr
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Espanha