JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients.

Ji, Juan; Wu, Yeqing; Meng, Yan; Zhang, Lijuan; Feng, Guijuan; Xia, Yunfei; Xue, Wenrong; Zhao, Shuyang; Gu, Zhifeng; Shao, Xiaoyi

Ji, Juan; Wu, Yeqing; Meng, Yan; Zhang, Lijuan; Feng, Guijuan; Xia, Yunfei; Xue, Wenrong; Zhao, Shuyang; Gu, Zhifeng; Shao, Xiaoyi.

Afiliação

Ji J; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Wu Y; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Meng Y; Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200000, China.
Zhang L; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Feng G; Department of Stomatology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Xia Y; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Xue W; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Zhao S; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Gu Z; Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Shao X; Department of Immunology, Medical College, Nantong University, Nantong 226001, China.

Acta Biochim Biophys Sin (Shanghai) ; 49(3): 208-215, 2017 Mar 01.

Article em En | MEDLINE | ID: mdl-28177455

Assuntos

Medula Óssea/patologia; Senescência Celular; Janus Quinase 2/metabolismo; Lúpus Eritematoso Sistêmico/patologia; Células-Tronco Mesenquimais/patologia; Transdução de Sinais; Adolescente; Adulto; Medula Óssea/metabolismo; Estudos de Casos e Controles; Proliferação de Células; Células Cultivadas; Feminino; Humanos; Lúpus Eritematoso Sistêmico/metabolismo; Masculino; Células-Tronco Mesenquimais/metabolismo; Fosforilação; Fator de Transcrição STAT3/metabolismo; Adulto Jovem

Palavras-chave

IFN-Î³; JAK-STAT signaling; mesenchymal stem cells; senescence; systemic lupus erythematosus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Transdução de Sinais / Senescência Celular / Janus Quinase 2 / Células-Tronco Mesenquimais / Lúpus Eritematoso Sistêmico Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Acta Biochim Biophys Sin (Shanghai) Assunto da revista: BIOFISICA / BIOQUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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