Expanding the CRISPR Toolbox: Targeting RNA with Cas13b.

Barrangou, Rodolphe; Gersbach, Charles A

Barrangou, Rodolphe; Gersbach, Charles A.

Afiliação

Barrangou R; Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: rbarran@ncsu.edu.
Gersbach CA; Department of Biomedical Engineering, Center for Genomic & Computational Biology, Duke University, Durham, NC 27708, USA; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27708, USA.

Mol Cell ; 65(4): 582-584, 2017 Feb 16.

Article em En | MEDLINE | ID: mdl-28212745

ABSTRACT

ABSTRACT

In this issue of Molecular Cell, Smargon et al. (2017) unearth Cas13b from type VI-B CRISPR-Cas immune systems and characterize its RNA-guided, RNA-targeting activity, including regulation by the novel co-factors Csx27 and Csx28, as well as non-specific collateral RNA damage.

Assuntos

Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas; RNA; Sistemas CRISPR-Cas; Humanos; RNA Guia de Cinetoplastídeos/genética

Palavras-chave

CRISPR; Cas; Cas13b; genome editing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article

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