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Unusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne.
Hong, Li-Li; Yu, Hao-Bing; Wang, Jie; Jiao, Wei-Hua; Cheng, Bao-Hui; Yang, Fan; Zhou, Yong-Jun; Gu, Bin-Bin; Song, Shao-Jiang; Lin, Hou-Wen.
Afiliação
  • Hong LL; Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.
  • Yu HB; Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.
  • Wang J; Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
  • Jiao WH; Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.
  • Cheng BH; Shenzhen Key Laboratory of ENT, Longgang ENT hospital &Institute of ENT, Shenzhen 518172, P. R. China.
  • Yang F; Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.
  • Zhou YJ; Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.
  • Gu BB; Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.
  • Song SJ; Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
  • Lin HW; Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China.
Sci Rep ; 7: 43138, 2017 02 22.
Article em En | MEDLINE | ID: mdl-28224981
Hipposponlachnins A (1) and B (2), possessing an unprecedented tetracyclo [9.3.0.02,8.03,7] tetradecane ring system, and the probable biogenetic precursor [3, (1R*,2E,4R*,7E,10S*,11S*,12R*)-10, 18-diacetoxydolabella-2,7-dien-6-one] of 1‒2 were isolated from the South China Sea marine sponge Hippospongia lachne. The structures of the novel compounds were determined using integrated spectroscopic methods in combination with single-crystal X-ray diffraction analysis. Compounds 1‒2 showed potent inhibitory activity on the release of ß-hexosaminidase, a biomarker for degranulation, as well as the production of pro-inflammatory cytokine IL-4 and lipid mediator LTB4 in DNP-IgE-stimulated RBL-2H3 cells.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poríferos / Antialérgicos / Diterpenos / Organismos Aquáticos Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Sci Rep Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poríferos / Antialérgicos / Diterpenos / Organismos Aquáticos Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Sci Rep Ano de publicação: 2017 Tipo de documento: Article