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Brachytherapy as part of the conservative treatment for primary and recurrent vulvar carcinoma.
Castelnau-Marchand, P; Escande, A; Mazeron, R; Bentivegna, E; Cavalcanti, A; Gouy, S; Baratiny, C; Maroun, P; Morice, P; Haie-Meder, C; Chargari, C.
Afiliação
  • Castelnau-Marchand P; Brachytherapy Unit, Radiation Oncology, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Escande A; Brachytherapy Unit, Radiation Oncology, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Mazeron R; Brachytherapy Unit, Radiation Oncology, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Bentivegna E; Department of Surgery, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Cavalcanti A; Department of Surgery, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Gouy S; Department of Surgery, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Baratiny C; Brachytherapy Unit, Radiation Oncology, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Maroun P; Brachytherapy Unit, Radiation Oncology, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Morice P; Department of Surgery, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Haie-Meder C; Brachytherapy Unit, Radiation Oncology, Gustave Roussy, University Paris Saclay, Villejuif, France.
  • Chargari C; Brachytherapy Unit, Radiation Oncology, Gustave Roussy, University Paris Saclay, Villejuif, France; French Military Health Services Academy, Paris, France; Institut de Recherche Biomédicale des Armées, Brétigny sur Orge, France. Electronic address: cyrus.chargari@gustaveroussy.fr.
Brachytherapy ; 16(3): 518-525, 2017.
Article em En | MEDLINE | ID: mdl-28262516
ABSTRACT

PURPOSE:

There are only scarce data on the place of brachytherapy (BT) for treatment of vulvar carcinoma. Our institutional experience of interstitial BT for vulvar carcinoma patients is reported. METHODS AND MATERIALS Clinical records of patients receiving low-dose-rate or pulsed-dose-rate BT as part of the primary treatment for primary/recurrent vulvar squamous cell carcinoma or as part of postoperative treatment between 2000 and 2015 were included. Patients, tumors, and treatment characteristics as well as clinical outcome were examined.

RESULTS:

A total of 26 patients treated with BT were identified. BT was delivered as part of primary intent treatment for locally advanced/recurrent cancer in 11 patients and as part of postoperative treatment in 15 patients. Median age at time of BT was 63 years (range, 41-88 years). Pulsed-dose-rate and low-dose-rate were used in 15 patients and 11 patients, respectively. BT was performed as a boost to the tumor bed following external beam radiotherapy (n = 13) or as the sole irradiation modality (n = 13). Total median dose at the level of primary tumor was 60 GyEQD2 (range, 55-60 GyEQD2). With mean followup of 41 months (range, 5 months-11.3 years), 11 patients experienced tumor relapse, and in two of them, site of relapse was only local. Three-year estimated disease-free survival and overall survival rates were 57% (95% confidence interval 45-69%) and 81% (95% confidence interval 72-90%), respectively. All toxicities were Grade 2 or less.

CONCLUSIONS:

Interstitial BT used as part of the primary or postoperative treatment of vulvar carcinoma is feasible with a satisfactory toxicity profile. Prognosis remains, however, dismal, with a high frequency of failures in patients with locally advanced tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Vulvares / Braquiterapia / Carcinoma de Células Escamosas / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Brachytherapy Assunto da revista: RADIOTERAPIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Vulvares / Braquiterapia / Carcinoma de Células Escamosas / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Brachytherapy Assunto da revista: RADIOTERAPIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França