Astrocytic LRP1 Mediates Brain Aß Clearance and Impacts Amyloid Deposition.

Liu, Chia-Chen; Hu, Jin; Zhao, Na; Wang, Jian; Wang, Na; Cirrito, John R; Kanekiyo, Takahisa; Holtzman, David M; Bu, Guojun

Liu, Chia-Chen; Hu, Jin; Zhao, Na; Wang, Jian; Wang, Na; Cirrito, John R; Kanekiyo, Takahisa; Holtzman, David M; Bu, Guojun.

Afiliação

Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, bu.guojun@mayo.edu liu.chiachen@mayo.edu.
Hu J; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224.
Zhao N; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, 361102 China.
Wang J; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224.
Wang N; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224.
Cirrito JR; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224.
Kanekiyo T; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, 361102 China.
Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, and.
Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224.

J Neurosci ; 37(15): 4023-4031, 2017 04 12.

Article em En | MEDLINE | ID: mdl-28275161

Assuntos

Peptídeos beta-Amiloides/metabolismo; Astrócitos/metabolismo; Encéfalo/metabolismo; Fragmentos de Peptídeos/metabolismo; Placa Amiloide/metabolismo; Receptores de LDL/fisiologia; Proteínas Supressoras de Tumor/fisiologia; Animais; Astrócitos/patologia; Encéfalo/patologia; Células Cultivadas; Feminino; Humanos; Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade; Masculino; Camundongos; Camundongos Knockout

Palavras-chave

Alzheimer's disease; LRP1; amyloid-ß

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Encéfalo / Receptores de LDL / Astrócitos / Peptídeos beta-Amiloides / Placa Amiloide / Proteínas Supressoras de Tumor Limite: Animals / Female / Humans / Male Idioma: En Revista: J Neurosci Ano de publicação: 2017 Tipo de documento: Article

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