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Cattle breeding, trypanosomosis prevalence and drug resistance in Northern Togo.
Tchamdja, E; Kulo, A E; Vitouley, H S; Batawui, K; Bankolé, A A; Adomefa, K; Cecchi, G; Hoppenheit, A; Clausen, P H; De Deken, R; Van Den Abbeele, J; Marcotty, T; Delespaux, V.
Afiliação
  • Tchamdja E; Direction de l'Elevage, BP 4041, Lomé, Togo.
  • Kulo AE; Ecole Supérieure d'Agronomie, Université de Lomé, BP 1515, Lomé, Togo.
  • Vitouley HS; Centre International de Recherche-Développement sur l'Elevage en Zone Subhumide (CIRDES), 01BP454 Bobo Dioulasso 01, Burkina Faso.
  • Batawui K; Direction de l'Elevage, BP 4041, Lomé, Togo.
  • Bankolé AA; Direction de l'Elevage, BP 4041, Lomé, Togo.
  • Adomefa K; Direction de l'Elevage, BP 4041, Lomé, Togo.
  • Cecchi G; Food and Agriculture Organization of the United Nations, Sub-Regional Office for Eastern Africa, Addis Ababa, Ethiopia.
  • Hoppenheit A; Freie Universitaet Berlin, Institute of Parasitology and Tropical Veterinary Medicine, Robert-von-Ostertagstr. 7-13, 14163 Berlin, Germany.
  • Clausen PH; Freie Universitaet Berlin, Institute of Parasitology and Tropical Veterinary Medicine, Robert-von-Ostertagstr. 7-13, 14163 Berlin, Germany.
  • De Deken R; Institute of Tropical Medicine, Biomedical Sciences Department, Veterinary Entomology, Nationalestraat 155, B-2000 Antwerp, Belgium.
  • Van Den Abbeele J; Institute of Tropical Medicine, Biomedical Sciences Department, Veterinary Protozoology, Nationalestraat 155, B-2000 Antwerp, Belgium.
  • Marcotty T; Veterinary Epidemiology, Risk-analysis and Diagnosis Research & Development, VERDI - R&D (asbl), Rue du gravier, 7, B-4141 Louveigné, Belgium.
  • Delespaux V; Vrije Universiteit Brussel, Faculty of Sciences and Bioengineering Sciences, Pleinlaan 2, B-1050 Brussels, Belgium. Electronic address: Vincent.Delespaux@vub.ac.be.
Vet Parasitol ; 236: 86-92, 2017 Mar 15.
Article em En | MEDLINE | ID: mdl-28288771
African Animal Trypanosomosis (AAT) is a major disease of cattle in Togo and its control is essentially based on chemotherapy. However, because of excessive use of trypanocides during the past decades, chemo-resistance in the parasites has developed. In order to assess the current situation of AAT and resistance to trypanocidal drugs in Northern Togo, a study was conducted on cattle from December 2012 to August 2013 in the regions of Kara and Savanes. An initial cross-sectional survey was carried out in 40 villages using the Haematocrit Centrifugation Technique (HCT). Out of these, 5 villages with a trypanosome prevalence of >10% were selected for a block treatment study (BT) with diminazene diaceturate (DA: 3.5mg/kg for a 14-day follow-up) and isometamidium chloride (ISM: 0.5mg/kg for a 28-day follow-up). Positive blood samples collected during the parasitological surveys and an equivalent number of negatives were further analyzed by PCR-RFLP for trypanosome species confirmation and molecular diagnosis of resistance to DA in Trypanosoma congolense. The results from 1883 bovine blood samples confirmed a high overall trypanosome prevalence of 10.8% in Northern Togo. PCR-RFLP revealed that T. congolense is the dominant pathogenic trypanosome species (50.5%) followed by T. vivax (27.3%), and T. brucei (16.2%). The BT showed varying levels of treatment failures ranging from 0 to 30% and from 0 to 50% for DA and for ISM respectively, suggesting the existence of resistant trypanosome populations in the study area. Our results show that AAT still represents a major obstacle to the development of cattle husbandry in Northern Togo. In areas of high AAT risk, a community-based integrated strategy combining vector control, rational use of trypanocidal drugs and improving the general condition of the animals is recommended to decision makers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Tripanossomíase Africana / Tripanossomíase Bovina / Trypanosoma congolense / Resistência a Medicamentos / Doenças dos Bovinos Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Animals País/Região como assunto: Africa Idioma: En Revista: Vet Parasitol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Togo

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Tripanossomíase Africana / Tripanossomíase Bovina / Trypanosoma congolense / Resistência a Medicamentos / Doenças dos Bovinos Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Animals País/Região como assunto: Africa Idioma: En Revista: Vet Parasitol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Togo