Pilot cohort study on the potential role of TCF7L2 rs7903146 on ischemic heart disease among non-diabetic kidney transplant recipients.
Clin Transplant
; 31(6)2017 06.
Article
em En
| MEDLINE
| ID: mdl-28299838
ABSTRACT
BACKGROUND:
TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated. On this basis, we investigated its association with major adverse cardiac events (MACE) in a single-center cohort of non-diabetic kidney transplant recipients (KTRs).METHODS:
Patients with pretransplant diabetes were excluded and patients who developed post-transplant diabetes were censored at time of diagnosis.RESULTS:
rs7903146 C>T polymorphism appeared to modulate the risk of MACE 5-year prevalence was 0.8% in CC patients, 7.2% in CT patients and 9.7% in TT patients (P<.001). TCF7L2 rs7903146 was an independent predictor of MACE in a multivariate Cox regression model (for each T allele, HR 2.99, 95%CI 1.62-5.52, P<.001), together with history of cardiac ischemic events (HR 8.69, 95%CI 3.57-21.16, P<.001), DGF (HR 2.42, 95%CI 0.98-5.95, P=.056) and HLA-mismatches (for each mismatch HR 1.55, 95%CI 1.00-2.43, P=.053). Introduction of rs7903146 C>T polymorphism into a model based on these clinical variables significantly increased predictive power for MACE (P=.003).CONCLUSIONS:
TCF7L2 rs7903146 T allele may be strongly and independently associated with MACE in non-diabetic KTRs. These findings suggest the possibility of employing this SNP to more accurately stratify cardiological risk in KTRs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Transplante de Rim
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Isquemia Miocárdica
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Polimorfismo de Nucleotídeo Único
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Proteína 2 Semelhante ao Fator 7 de Transcrição
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Falência Renal Crônica
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Clin Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Itália