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Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells.
Salazar, Tatiana E; Richardson, Matthew R; Beli, Eleni; Ripsch, Matthew S; George, John; Kim, Youngsook; Duan, Yaqian; Moldovan, Leni; Yan, Yuanqing; Bhatwadekar, Ashay; Jadhav, Vaishnavi; Smith, Jared A; McGorray, Susan; Bertone, Alicia L; Traktuev, Dmitri O; March, Keith L; Colon-Perez, Luis M; Avin, Keith G; Sims, Emily; Mund, Julie A; Case, Jamie; Deng, Xiaolin; Kim, Min Su; McDavitt, Bruce; Boulton, Michael E; Thinschmidt, Jeffrey; Li Calzi, Sergio; Fitz, Stephanie D; Fuchs, Robyn K; Warden, Stuart J; McKinley, Todd; Shekhar, Anantha; Febo, Marcelo; Johnson, Phillip L; Chang, Lung-Ji; Gao, Zhanguo; Kolonin, Mikhail G; Lai, Song; Ma, Jingfeng; Dong, Xinzhong; White, Fletcher A; Xie, Huisheng; Yoder, Mervin C; Grant, Maria B.
Afiliação
  • Salazar TE; Genetics Institute, Gainesville, Florida, USA.
  • Richardson MR; College of Medicine, Gainesville, Florida, USA.
  • Beli E; Department of Ophthalmology, Indianapolis, Indiana, USA.
  • Ripsch MS; Wells Center for Pediatric Research, Indianapolis, Indiana, USA.
  • George J; Department of Ophthalmology, Indianapolis, Indiana, USA.
  • Kim Y; Department of Anesthesia, Indianapolis, Indiana, USA.
  • Duan Y; Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, USA.
  • Moldovan L; College of Medicine, Gainesville, Florida, USA.
  • Yan Y; Department of Anesthesia, Indianapolis, Indiana, USA.
  • Bhatwadekar A; Department of Ophthalmology, Indianapolis, Indiana, USA.
  • Jadhav V; Department of Ophthalmology, Indianapolis, Indiana, USA.
  • Smith JA; Genetics Institute, Gainesville, Florida, USA.
  • McGorray S; Department of Ophthalmology, Indianapolis, Indiana, USA.
  • Bertone AL; Department of Anesthesia, Indianapolis, Indiana, USA.
  • Traktuev DO; Department of Anesthesia, Indianapolis, Indiana, USA.
  • March KL; Department of Biostatistics, Gainesville, Florida, USA.
  • Colon-Perez LM; Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA.
  • Avin KG; Krannert Institute of Cardiology, Indianapolis, Indiana, USA.
  • Sims E; Indiana Center for Vascular Biology and Medicine, Indianapolis, Indiana, USA.
  • Mund JA; Krannert Institute of Cardiology, Indianapolis, Indiana, USA.
  • Case J; Indiana Center for Vascular Biology and Medicine, Indianapolis, Indiana, USA.
  • Deng X; Department of Psychiatry, McKnight Brain Institute, Gainesville, Florida, USA.
  • Kim MS; Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indianapolis, Indiana, USA.
  • McDavitt B; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.
  • Boulton ME; Wells Center for Pediatric Research, Indianapolis, Indiana, USA.
  • Thinschmidt J; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.
  • Li Calzi S; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.
  • Fitz SD; Scripps Clinic Medical Group, Scripps Center for Organ and Cell Transplantation, La Jolla, California, USA.
  • Fuchs RK; Mainland Acupuncture Center, Gainesville, Florida, USA.
  • Warden SJ; College of Veterinary Medicine, Chon Buk National University, Jeonju, South Korea.
  • McKinley T; McDavitt Veterinary Clinic, Zionsville, Indiana, USA.
  • Shekhar A; Department of Ophthalmology, Indianapolis, Indiana, USA.
  • Febo M; Department of Pharmacology and Therapeutics, Gainesville, Florida, USA.
  • Johnson PL; Department of Ophthalmology, Indianapolis, Indiana, USA.
  • Chang LJ; Department of Psychiatry, Indianapolis, Indiana, USA.
  • Gao Z; Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indianapolis, Indiana, USA.
  • Kolonin MG; Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indianapolis, Indiana, USA.
  • Lai S; Department of Orthopedic Surgery, Indianapolis, Indiana, USA.
  • Ma J; Department of Psychiatry, Indianapolis, Indiana, USA.
  • Dong X; Department of Psychiatry, McKnight Brain Institute, Gainesville, Florida, USA.
  • White FA; Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Xie H; Department of Molecular Genetics and Microbiology, Gainesville, Florida, USA.
  • Yoder MC; School of Medicine, University of Electronic Science and Technology of China, Sichuan, China.
  • Grant MB; The Brown Foundation, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA.
Stem Cells ; 35(5): 1303-1315, 2017 05.
Article em En | MEDLINE | ID: mdl-28299842
ABSTRACT
Electroacupuncture (EA) performed in rats and humans using limb acupuncture sites, LI-4 and LI-11, and GV-14 and GV-20 (humans) and Bai-hui (rats) increased functional connectivity between the anterior hypothalamus and the amygdala and mobilized mesenchymal stem cells (MSCs) into the systemic circulation. In human subjects, the source of the MSC was found to be primarily adipose tissue, whereas in rodents the tissue sources were considered more heterogeneous. Pharmacological disinhibition of rat hypothalamus enhanced sympathetic nervous system (SNS) activation and similarly resulted in a release of MSC into the circulation. EA-mediated SNS activation was further supported by browning of white adipose tissue in rats. EA treatment of rats undergoing partial rupture of the Achilles tendon resulted in reduced mechanical hyperalgesia, increased serum interleukin-10 levels and tendon remodeling, effects blocked in propranolol-treated rodents. To distinguish the afferent role of the peripheral nervous system, phosphoinositide-interacting regulator of transient receptor potential channels (Pirt)-GCaMP3 (genetically encoded calcium sensor) mice were treated with EA acupuncture points, ST-36 and LIV-3, and GV-14 and Bai-hui and resulted in a rapid activation of primary sensory neurons. EA activated sensory ganglia and SNS centers to mediate the release of MSC that can enhance tissue repair, increase anti-inflammatory cytokine production and provide pronounced analgesic relief. Stem Cells 2017;351303-1315.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eletroacupuntura / Sistema Nervoso Central / Células-Tronco Mesenquimais Limite: Animals / Humans Idioma: En Revista: Stem Cells Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eletroacupuntura / Sistema Nervoso Central / Células-Tronco Mesenquimais Limite: Animals / Humans Idioma: En Revista: Stem Cells Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos