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Human mass balance study and metabolite profiling of 14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer.
van Andel, Lotte; Zhang, Z; Lu, S; Kansra, V; Agarwal, S; Hughes, L; Tibben, M M; Gebretensae, A; Lucas, L; Hillebrand, M J X; Rosing, H; Schellens, J H M; Beijnen, J H.
Afiliação
  • van Andel L; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands. l.v.andel@nki.nl.
  • Zhang Z; Tesaro Inc., Waltham, MA, USA.
  • Lu S; Tesaro Inc., Waltham, MA, USA.
  • Kansra V; Tesaro Inc., Waltham, MA, USA.
  • Agarwal S; Tesaro Inc., Waltham, MA, USA.
  • Hughes L; Tesaro Inc., Waltham, MA, USA.
  • Tibben MM; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Gebretensae A; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Lucas L; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Hillebrand MJX; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Rosing H; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital / The Netherlands Cancer Institute and MC Slotervaart, P.O. Box 90440, 1006 BK, Amsterdam, The Netherlands.
  • Schellens JHM; Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Beijnen JH; Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Invest New Drugs ; 35(6): 751-765, 2017 12.
Article em En | MEDLINE | ID: mdl-28303528
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Piperidinas / Neoplasias da Mama / Radioisótopos de Carbono / Neoplasias Colorretais / Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 / Indazóis Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Piperidinas / Neoplasias da Mama / Radioisótopos de Carbono / Neoplasias Colorretais / Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 / Indazóis Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda