Phenacyl azides as efficient intermediates: one-pot synthesis of pyrrolidines and imidazoles.
Org Biomol Chem
; 15(13): 2730-2733, 2017 Mar 28.
Article
em En
| MEDLINE
| ID: mdl-28304056
ABSTRACT
Phenacyl azides were decomposed in basic media to generate N-unsubstituted imines which were reacted with cyclic amino acids to give an azomethine ylide that underwent [3 + 2] cycloaddition with maleimides and N-unsubstituted imines to yield various diastereoselective pyrrolidines and imidazoles respectively in a one-pot three component manner with good to excellent yields.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2017
Tipo de documento:
Article