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3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H.
Huber, Andrew D; Michailidis, Eleftherios; Tang, Jing; Puray-Chavez, Maritza N; Boftsi, Maria; Wolf, Jennifer J; Boschert, Kelsey N; Sheridan, Megan A; Leslie, Maxwell D; Kirby, Karen A; Singh, Kamalendra; Mitsuya, Hiroaki; Parniak, Michael A; Wang, Zhengqiang; Sarafianos, Stefan G.
Afiliação
  • Huber AD; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
  • Michailidis E; Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.
  • Tang J; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
  • Puray-Chavez MN; Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.
  • Boftsi M; Center for Drug Design, University of Minnesota, Minneapolis, Minnesota, USA.
  • Wolf JJ; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
  • Boschert KN; Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.
  • Sheridan MA; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
  • Leslie MD; Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.
  • Kirby KA; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
  • Singh K; Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.
  • Mitsuya H; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
  • Parniak MA; Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.
  • Wang Z; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
  • Sarafianos SG; Department of Biochemistry, University of Missouri, Columbia, Missouri, USA.
Antimicrob Agents Chemother ; 61(6)2017 06.
Article em En | MEDLINE | ID: mdl-28320718
ABSTRACT
Hepatitis B virus (HBV) RNase H (RNH) is an appealing therapeutic target due to its essential role in viral replication. RNH inhibitors (RNHIs) could help to more effectively control HBV infections. Here, we report 3-hydroxypyrimidine-2,4-diones as novel HBV RNHIs with antiviral activity. We synthesized and tested 52 analogs and found 4 that inhibit HBV RNH activity in infected cells. Importantly, 2 of these compounds inhibited HBV replication in the low micromolar range.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite B / Ribonuclease H Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite B / Ribonuclease H Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos