Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents.

Lottrup, Grete; Belling, Kirstine; Leffers, Henrik; Nielsen, John E; Dalgaard, Marlene D; Juul, Anders; Skakkebæk, Niels E; Brunak, Søren; Rajpert-De Meyts, Ewa

Lottrup, Grete; Belling, Kirstine; Leffers, Henrik; Nielsen, John E; Dalgaard, Marlene D; Juul, Anders; Skakkebæk, Niels E; Brunak, Søren; Rajpert-De Meyts, Ewa.

Afiliação

Lottrup G; Department of Growth and Reproduction, Copenhagen University Hospital(Rigshospitalet), International Center for Research and Training in Endocrine Disruption of Male Reproduction & Child Health (EDMaRC), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.
Belling K; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Leffers H; Department of Growth and Reproduction, Copenhagen University Hospital(Rigshospitalet), International Center for Research and Training in Endocrine Disruption of Male Reproduction & Child Health (EDMaRC), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.
Nielsen JE; Department of Growth and Reproduction, Copenhagen University Hospital(Rigshospitalet), International Center for Research and Training in Endocrine Disruption of Male Reproduction & Child Health (EDMaRC), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.
Dalgaard MD; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), International Center for Research and Training in Endocrine Disruption of Male Reproduction & Child Health (EDMaRC), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.
Juul A; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark (DTU), DK-2800 Lyngby, Denmark.
Skakkebæk NE; DTU Multi-Assay Core (DMAC), Department of Biotechnology and Biomedicine, DTU Bioengineering, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Brunak S; Department of Growth and Reproduction, Copenhagen University Hospital(Rigshospitalet), International Center for Research and Training in Endocrine Disruption of Male Reproduction & Child Health (EDMaRC), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.
Rajpert-De Meyts E; Department of Growth and Reproduction, Copenhagen University Hospital(Rigshospitalet), International Center for Research and Training in Endocrine Disruption of Male Reproduction & Child Health (EDMaRC), 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.

Mol Hum Reprod ; 23(5): 339-354, 2017 05 01.

Article em En | MEDLINE | ID: mdl-28333300

Assuntos

Regulação da Expressão Gênica no Desenvolvimento; Células Intersticiais do Testículo/metabolismo; Neoplasias Embrionárias de Células Germinativas/genética; Neoplasias Testiculares/genética; Transcriptoma; Adulto; Proteínas de Sinalização Intercelular CCN/genética; Proteínas de Sinalização Intercelular CCN/metabolismo; Estudos de Casos e Controles; Feto; Perfilação da Expressão Gênica; Humanos; Hidroxiprostaglandina Desidrogenases/genética; Hidroxiprostaglandina Desidrogenases/metabolismo; Células Intersticiais do Testículo/citologia; Masculino; Neoplasias Embrionárias de Células Germinativas/patologia; Análise de Sequência com Séries de Oligonucleotídeos; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo; Espermatogênese/genética; Sulfotransferases/genética; Sulfotransferases/metabolismo; Neoplasias Testiculares/patologia

Palavras-chave

Leydig cell; Leydig cell hyperplasia; Leydig cell micronodules; foetal Leydig cell; gene expression profiling; human testis; testicular germ cell tumours; transcriptome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Neoplasias Embrionárias de Células Germinativas / Regulação da Expressão Gênica no Desenvolvimento / Transcriptoma / Células Intersticiais do Testículo Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Mol Hum Reprod Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA REPRODUTIVA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Dinamarca

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