Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population.
J Cancer
; 8(4): 531-536, 2017.
Article
em En
| MEDLINE
| ID: mdl-28367233
ABSTRACT
Background:
Genome-wide association studies have identified that polymorphisms in 8q24 confer susceptibility to gastric cancer. Polymorphisms in the lncRNA PRNCR1, PCAT1, and CCAT2 transcribed from the 8q24 locus have a potential risk for gastric cancer.Methods:
To evaluate whether there is such an association in Chinese population, a case-control study enrolled 494 patients and 494 healthy controls was carried out. Sequenom MassARRAY platform was used for genotyping.Results:
This study showed that rs16901946 G allele was associated with increased risk of gastric cancer (AG adjusted OR = 1.33, 95% CI =1.02-1.73, p=0.033; GG adjusted OR = 2.07; 95% CI = 1.11-3.86, p=0.023, AG/GG adjusted OR = 1.39, 95% CI = 1.08-1.1.79, p=0.011; additive model adjusted OR = 1.37; 95% CI = 1.10-1.70, p=0.004). Stratified analysis revealed that the increased risk was more evident in the cohort of younger subjects (adjusted OR = 1.84, 95% CI = 1.18-2.87, p=0.007), males (adjusted OR = 1.55, 95% CI = 1.15-2.08, p=0.004), positive Helicobacter pylori infection (adjusted OR = 1.44, 95% CI = 1.02-2.03, p=0.041), gastric cardia adenocarcinoma (adjusted OR = 1.61, 95% CI = 1.10-2.35, p=0.014), and tumor stage T1-T2 (adjusted OR = 1.58, 95% CI = 1.10-2.28, p=0.013).Conclusions:
Our study suggested that rs16901946 G allele carriers have an increased risk of gastric cancer, and the risk could be enhanced by the interactions between the polymorphism and age, sex, Helicobacter pylori infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Cancer
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China