High doses of vitamin C plus E reduce strength training-induced improvements in areal bone mineral density in elderly men.
Eur J Appl Physiol
; 117(6): 1073-1084, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28382551
ABSTRACT
PURPOSE:
Resistance training is beneficial for maintaining bone mass. We aimed to investigate the skeletal effects of high doses of antioxidants [vitamin C + E (α-tocopherol)] supplementation during 12-week supervised strength training in healthy, elderly menMETHODS:
Design:
double-blinded randomized placebo-controlled study. Participants followed a supervised, undulating periodic exercise program with weekly adjusted load 3 sessions/week and 3-15 repetitions maximum (RM) sets/exercise. The control group (CG, n = 17, 67 ± 5 years) received placebo and the antioxidant group (AO, n = 16, 70 ± 7 years) 1000 mg vitamin C + 235 mg vitamin E, daily. Areal bone mineral density (aBMD) at whole body, lumbar spine (L1-L4), total hip, and femoral neck were measured by dual energy X-ray absorptiometry and muscle strength by 1RM. Serum analyses of bone-related factors and adipokines were performed.RESULTS:
In the CG, total hip aBMD increased by 1.0% (CI 0.3-1.7) versus pretest and lumbar spine aBMD increased by 0.9% (CI -0.2 to 2.0) compared to the AO. In the CG, there was an increase in serum concentrations of insulin-like growth factor 1 [+27.3% (CI -0.3 to 54.9)] and leptin [+31.2% (CI 9.8-52.6)) versus pretest, and a decrease in sclerostin [-9.9% (CI 4.4-15.3)] versus pretest and versus AO. Serum bone formation markers P1NP and osteocalcin increased in both groups, while the bone resorption marker CTX-1 remained unchanged.CONCLUSION:
High doses of antioxidant supplementations may constrain the favorable skeletal benefits of 12 weeks of resistance exercise in healthy elderly men.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Vitamina E
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Vitaminas
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Densidade Óssea
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Treinamento Resistido
Tipo de estudo:
Clinical_trials
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Appl Physiol
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Noruega