YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma.

Kojima, Yuki; Hayakawa, Fumihiko; Morishita, Takanobu; Sugimoto, Keiki; Minamikawa, Yuka; Iwase, Mizuho; Yamamoto, Hideyuki; Hirano, Daiki; Imoto, Naoto; Shimada, Kazuyuki; Okada, Seiji; Kiyoi, Hitoshi

Kojima, Yuki; Hayakawa, Fumihiko; Morishita, Takanobu; Sugimoto, Keiki; Minamikawa, Yuka; Iwase, Mizuho; Yamamoto, Hideyuki; Hirano, Daiki; Imoto, Naoto; Shimada, Kazuyuki; Okada, Seiji; Kiyoi, Hitoshi.

Afiliação

Kojima Y; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hayakawa F; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: bun-hy@med.nagoya-u.ac.jp.
Morishita T; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Hematology, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan.
Sugimoto K; Fujii Memorial Research Institute, Otsuka Pharmaceutical Co., Ltd., Otsu, Japan.
Minamikawa Y; Department of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Iwase M; Department of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Yamamoto H; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hirano D; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Imoto N; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Hematology, Ogaki Municipal Hospital, Gifu, Japan.
Shimada K; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Okada S; Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
Kiyoi H; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Pharmacol Res ; 120: 242-251, 2017 Jun.

Article em En | MEDLINE | ID: mdl-28396094

Assuntos

Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Imidazóis/uso terapêutico; Linfoma de Efusão Primária/tratamento farmacológico; Proteína de Sequência 1 de Leucemia de Células Mieloides/metabolismo; Naftoquinonas/uso terapêutico; Proteólise/efeitos dos fármacos; Animais; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Imidazóis/farmacologia; Linfoma de Efusão Primária/metabolismo; Linfoma de Efusão Primária/patologia; Masculino; Camundongos Endogâmicos NOD; Camundongos SCID; Naftoquinonas/farmacologia; Complexo de Endopeptidases do Proteassoma/metabolismo

Palavras-chave

6-BIO (PubChem CID: 11405589); Chicago sky blue 6B (PubChem CID: 9566045); Daunorubicin (PubChem CID: 62770); Drug screening; HIV; Idarubicin (PubChem CID: 636362); Licochalcone A (PubChem CID: 5318998); Mitoxantrone (PubChem CID: 51082); Patient-derived xenograft; Phorbol 12-myristate 13-acetate (PubChem CID: 27924); Primary effusion lymphoma; Pyurvinium pamoate (PubChem CID: 7847555); Tomatine (PubChem CID: 23760126); U0126 (PubChem CID: 5354033); Valproic Acid Sodium Salt (PubChem CID: 24277744); Verteporfin (PubChem CID: 5362420); YM155; YM155 (PubChem CID: 11178236); Z-VAD-FMK (PubChem CID: 5497174)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Apoptose / Linfoma de Efusão Primária / Proteólise / Proteína de Sequência 1 de Leucemia de Células Mieloides / Imidazóis / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão

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