Histological Features of Methylene Blue-Induced Phototoxicity Administered in the Context of Parathyroid Surgery.
Am J Dermatopathol
; 39(8): e110-e115, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28398918
ABSTRACT
Methylene blue is a chromophore dye known for its photosensitizing properties. It is also administered intravenously as a tracer in parathyroid surgery to identify abnormal glands. We describe 2 cases of acute methylene blue-induced phototoxicity in patients who underwent parathyroidectomy. Both patients developed an acute vesiculopustular inflammatory rash on the anterior neck corresponding to the site exposed intraoperatively to overhanging surgical lights. One of the patients also developed a bulla on her finger at the site of attachment of the oxygen probe. Biopsies were taken from both patients at different time points. The histological findings included destruction of sebaceous glands and deposition of diastase-periodic acid-Schiff-positive hyaline material around dermal blood vessels. These features are similar to those seen in skin treated with photodynamic therapy and systemic photosensitivity disorders such as the porphyrias. The wavelengths of light emitted by the surgical lights and oxygen probe overlap with the absorption spectrum of methylene blue. This resulted in excitation of the systemically administered methylene blue at exposed sites, with resultant local tissue damage and a phototoxic reaction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paratireoidectomia
/
Dermatite Fototóxica
/
Corantes
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Azul de Metileno
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
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Humans
/
Middle aged
Idioma:
En
Revista:
Am J Dermatopathol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido