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Virus genomes reveal factors that spread and sustained the Ebola epidemic.
Dudas, Gytis; Carvalho, Luiz Max; Bedford, Trevor; Tatem, Andrew J; Baele, Guy; Faria, Nuno R; Park, Daniel J; Ladner, Jason T; Arias, Armando; Asogun, Danny; Bielejec, Filip; Caddy, Sarah L; Cotten, Matthew; D'Ambrozio, Jonathan; Dellicour, Simon; Di Caro, Antonino; Diclaro, Joseph W; Duraffour, Sophie; Elmore, Michael J; Fakoli, Lawrence S; Faye, Ousmane; Gilbert, Merle L; Gevao, Sahr M; Gire, Stephen; Gladden-Young, Adrianne; Gnirke, Andreas; Goba, Augustine; Grant, Donald S; Haagmans, Bart L; Hiscox, Julian A; Jah, Umaru; Kugelman, Jeffrey R; Liu, Di; Lu, Jia; Malboeuf, Christine M; Mate, Suzanne; Matthews, David A; Matranga, Christian B; Meredith, Luke W; Qu, James; Quick, Joshua; Pas, Suzan D; Phan, My V T; Pollakis, Georgios; Reusken, Chantal B; Sanchez-Lockhart, Mariano; Schaffner, Stephen F; Schieffelin, John S; Sealfon, Rachel S; Simon-Loriere, Etienne.
Afiliação
  • Dudas G; Institute of Evolutionary Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3FL, UK.
  • Carvalho LM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Bedford T; Institute of Evolutionary Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3FL, UK.
  • Tatem AJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Baele G; WorldPop, Department of Geography and Environment, University of Southampton, Highfield, Southampton SO17 1BJ, UK.
  • Faria NR; Flowminder Foundation, Stockholm, Sweden.
  • Park DJ; Department of Microbiology and Immunology, Rega Institute, KU Leuven - University of Leuven, 3000 Leuven, Belgium.
  • Ladner JT; Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
  • Arias A; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
  • Asogun D; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA.
  • Bielejec F; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
  • Caddy SL; National Veterinary Institute, Technical University of Denmark, Bülowsvej 27, 1870, Frederiksberg C, Denmark.
  • Cotten M; Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Nigeria.
  • D'Ambrozio J; The European Mobile Laboratory Consortium, 20359 Hamburg, Germany.
  • Dellicour S; Department of Microbiology and Immunology, Rega Institute, KU Leuven - University of Leuven, 3000 Leuven, Belgium.
  • Di Caro A; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
  • Diclaro JW; Virus Genomics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Duraffour S; Department of Viroscience, Erasmus University Medical Centre, PO Box 2040, 300 CA Rotterdam, the Netherlands.
  • Elmore MJ; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA.
  • Fakoli LS; Department of Microbiology and Immunology, Rega Institute, KU Leuven - University of Leuven, 3000 Leuven, Belgium.
  • Faye O; The European Mobile Laboratory Consortium, 20359 Hamburg, Germany.
  • Gilbert ML; National Institute for Infectious Diseases 'L. Spallanzani'-IRCCS, Via Portuense 292, 00149 Rome, Italy.
  • Gevao SM; Naval Medical Research Unit 3, 3A Imtidad Ramses Street, Cairo 11517, Egypt.
  • Gire S; The European Mobile Laboratory Consortium, 20359 Hamburg, Germany.
  • Gladden-Young A; Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
  • Gnirke A; National Infections Service, Public Health England, Porton Down, Salisbury, Wilts SP4 0JG, UK.
  • Goba A; Liberian Institute for Biomedical Research, Charlesville, Liberia.
  • Grant DS; Institut Pasteur de Dakar, Arbovirus and Viral Hemorrhagic Fever Unit, 36 Avenue Pasteur, BP 220, Dakar, Sénégal.
  • Haagmans BL; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA.
  • Hiscox JA; University of Sierra Leone, Freetown, Sierra Leone.
  • Jah U; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
  • Kugelman JR; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
  • Liu D; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
  • Lu J; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
  • Malboeuf CM; Viral Hemorrhagic Fever Program, Kenema Government Hospital, 1 Combema Road, Kenema, Sierra Leone.
  • Mate S; Ministry of Health and Sanitation, 4th Floor Youyi Building, Freetown, Sierra Leone.
  • Matthews DA; Viral Hemorrhagic Fever Program, Kenema Government Hospital, 1 Combema Road, Kenema, Sierra Leone.
  • Matranga CB; Ministry of Health and Sanitation, 4th Floor Youyi Building, Freetown, Sierra Leone.
  • Meredith LW; Department of Viroscience, Erasmus University Medical Centre, PO Box 2040, 300 CA Rotterdam, the Netherlands.
  • Qu J; Institute of Infection and Global Health, University of Liverpool, Liverpool L69 2BE, UK.
  • Quick J; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool L69 3GL, UK.
  • Pas SD; University of Makeni, Makeni, Sierra Leone.
  • Phan MVT; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA.
  • Pollakis G; Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
  • Reusken CB; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
  • Sanchez-Lockhart M; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
  • Schaffner SF; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA.
  • Schieffelin JS; University of Bristol, Bristol BS8 1TD, UK.
  • Sealfon RS; Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
  • Simon-Loriere E; Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Nature ; 544(7650): 309-315, 2017 04 20.
Article em En | MEDLINE | ID: mdl-28405027
ABSTRACT
The 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Viral / Doença pelo Vírus Ebola / Ebolavirus Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Viral / Doença pelo Vírus Ebola / Ebolavirus Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido