Rotundarpene inhibits TNF-&#945;-induced activation of the Akt, mTOR, and NF-&#954;B pathways, and the JNK and p38 associated with production of reactive oxygen species.

Kim, Arum; Nam, Yoon Jeong; Shin, Yong Kyoo; Lee, Min Sung; Sohn, Dong Suep; Lee, Chung Soo

Rotundarpene inhibits TNF-α-induced activation of the Akt, mTOR, and NF-κB pathways, and the JNK and p38 associated with production of reactive oxygen species.

Kim, Arum; Nam, Yoon Jeong; Shin, Yong Kyoo; Lee, Min Sung; Sohn, Dong Suep; Lee, Chung Soo.

Afiliação

Kim A; Department of Pharmacology, College of Medicine, and The BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea.
Nam YJ; Department of Pharmacology, College of Medicine, and The BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea.
Shin YK; Department of Pharmacology, College of Medicine, and The BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea.
Lee MS; Department of Internal Medicine, SoonChunHyang University Hospital, Bucheon, Kyung-Gi-Do, 420-767, South Korea.
Sohn DS; Department of Thoracic and Cardiovascular Surgery, Chung-Ang University Hospital, Seoul, 156-755, South Korea.
Lee CS; Department of Pharmacology, College of Medicine, and The BK21plus Skin Barrier Network Human Resources Development Team, Chung-Ang University, Seoul, 156-756, South Korea. leecs@cau.ac.kr.

Mol Cell Biochem ; 434(1-2): 113-125, 2017 Oct.

Article em En | MEDLINE | ID: mdl-28432555

Assuntos

Ácidos Cafeicos/farmacologia; Hemiterpenos/farmacologia; MAP Quinase Quinase 4/metabolismo; NF-kappa B/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Fator de Necrose Tumoral alfa/fisiologia; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Western Blotting; Células Cultivadas; Quimiocinas/metabolismo; Citocinas/metabolismo; Ensaio de Imunoadsorção Enzimática; Humanos; Mediadores da Inflamação/antagonistas & inibidores; Mediadores da Inflamação/metabolismo; NF-kappa B/antagonistas & inibidores; Fosforilação; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Serina-Treonina Quinases TOR/antagonistas & inibidores

Palavras-chave

Akt, mTOR and NF-κB pathways; Inflammatory mediator production; JNK and p38-MAPK; Keratinocytes; Rotundarpene; Tumor necrosis factor-α

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Cafeicos / NF-kappa B / Fator de Necrose Tumoral alfa / Espécies Reativas de Oxigênio / Hemiterpenos / MAP Quinase Quinase 4 / Proteínas Quinases p38 Ativadas por Mitógeno / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Mol Cell Biochem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Coréia do Sul

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google